Results 51 to 60 of about 988,906 (309)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Extending the host range of Listeria monocytogenes by rational protein design [PDF]

, 2007
In causing disease, pathogens outmaneuver host defenses through a dedicated arsenal of virulence determinants that specifically bind or modify individual host molecules. This dedication limits the intruder to a defined range of hosts.
Wollert, Thomas, Gruber, A.D., Heinz, D.W., Pasche, Bastian, van den Heuvel, Joop, Heinz, Dirk W., Lengeling, A., Gruber, Achim D., Heinz, Dirk W, van den Heuvel, J., Schubert, W.D., Rochon, M., Rochon, Maike, Schubert, Wolf-Dieter, Pasche, B., Lengeling, Andreas, Deppenmeier, Stefanie, Deppenmeier, S., Gruber, Achim D, Wollert, T.   +19 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Pseudogenes and host specialization in the emergent bacterial plant pathogen Xylella fastidiosa

Applied and Environmental Microbiology
Pseudogenes are regarded as “junk” DNA, representing vestigial functions no longer needed for fitness. Accordingly, a higher number of pseudogenes in a bacterial human pathogen was previously hypothesized to be a hallmark of host specialists.
Navdeep Kaur, Neha Potnis, Leonardo De La Fuente   +2 more
doaj   +1 more source

Host Range of Chlamydiaphages φCPAR39 and Chp3 [PDF]

Journal of Bacteriology, 2003
ABSTRACT The host range of φCPAR39 is limited to four Chlamydophila species: C. abortus , C. caviae , C. pecorum , and C. pneumoniae . Chp3 (a newly discovered bacteriophage isolated from C. pecorum
Everson, J.S., Garner, S.A., Lambden, P.R., Fane, B.A., Clarke, I.N.   +4 more
openaire   +3 more sources

Uncovering the transcriptional control of "Bartonella henselae" host adaptation factors [PDF]

, 2014
A recurrent theme in bacterial pathogenicity is the understanding of the regulatory events necessary for a given pathogen to progress through its infection cycle while resisting the host defense mechanisms.
Québatte, Maxime
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Trematode Infection Prevalence Increases With Snail Richness: Observations From a 4‐Year Study of Snail–Trematode Interactions

Ecology and Evolution
Digenetic trematodes are valuable study organisms for exploring how biodiversity influences disease. In this study, we investigated the relationship between snail richness and trematode infection prevalence using data from a 4‐year study (2019–2022) of ...
Brooke A. McPhail, Carol M. Frost, Simon J. G. Otto, Patrick C. Hanington   +3 more
doaj   +1 more source

Niche-Specificity and the Variable Fraction of the Pectobacterium Pan-Genome

Molecular Plant-Microbe Interactions, 2008
We compare genome sequences of three closely related soft-rot pathogens that vary in host range and geographical distribution to identify genetic differences that could account for lifestyle differences. The isolates compared, Pectobacterium atrosepticum
J. D. Glasner, M. Marquez-Villavicencio, H.-S. Kim, C. E. Jahn, B. Ma, B. S. Biehl, A. I. Rissman, B. Mole, X. Yi, C.-H. Yang, J. L. Dangl, S. R. Grant, N. T. Perna, A. O. Charkowski   +13 more
doaj   +1 more source

Determinants of Host Range Specificity in Legume-Rhizobia Symbiosis

Frontiers in Microbiology, 2020
Leguminous plants possess the almost unique ability to enter symbiosis with soil-resident, nitrogen fixing bacteria called rhizobia. During this symbiosis, the bacteria physically colonize specialized organs on the roots of the host plant called nodules,
Liam Walker, Beatriz Lagunas, Miriam L. Gifford, Miriam L. Gifford   +3 more
doaj   +1 more source