Results 71 to 80 of about 2,581,842 (305)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
California Agriculture, 1986 Widespread in the Imperial Valley, this needle nematode can cause severe seedling disease at relatively low ...
C Kolodge, J Radewald, F Shibuya
doaj
The Current Host Range of Hepatitis E Viruses
Viruses, 2019 Hepatitis E virus (HEV) is an emerging zoonotic pathogen transmitting both human to human via the fecal oral route and from animals to humans through feces, direct contact, and consumption of contaminated meat products.
Scott P Kenney
doaj +1 more source
Host-restricted Range of H5n1 Avian Influenza Viruses Associated with Characters of Polymerase Complex of Pb2 and Pb1-f2 Proteins [PDF]
, 2015 Epidemiological studies on H5N1 avian influenza viruses indi-cated that the viruses do not transmit efficiently from human to human. Transmissibility of viruses among human population is very complex and polygenic.
Dharmayanti, N. I. (NLP) +1 more
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The host-range tdCE phenotype of Chandipura virus is determined by mutations in the polymerase gene [PDF]
The emerging arbovirus Chandipura virus (CV) has been implicated in epidemics of acute encephalitis in India with high mortality rates. The isolation of temperature-dependent host-range (tdCE) mutants, which are impaired in growth at 39 °C in chick ...
Easton, A. J. (Andrew J.) +2 more
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Frontiers in Microbiology, 2020 Carbapenem-resistant Klebsiella pneumoniae (CRKP) poses a significant clinical problem given the lack of therapeutic options available. Alternative antibacterial agents, such as bacteriophages, can be used as a valuable tool to treat the infections ...
Min Li +18 more
doaj +1 more source
Adaptive Plasmid Evolution Results in Host-Range Expansion of a Broad-Host-Range Plasmid [PDF]
Genetics, 2008 Abstract Little is known about the range of hosts in which broad-host-range (BHR) plasmids can persist in the absence of selection for plasmid-encoded traits, and whether this “long-term host range” can evolve over time. Previously, the BHR multidrug resistance plasmid pB10 was shown to be highly unstable in Stenotrophomonas maltophilia ...
Leen, De Gelder +4 more
openaire +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Geographical distribution and aspects of the ecology of the hemiparasitic angiosperm Striga asiatica (L) Kuntze: A herbarium study [PDF]
, 1997 Striga asiatica (Scrophulariaceae) is an obligate root hemiparasite of mainly C-4 grasses (including cereals). It is the most widespread of the 42 Striga species occurring in many semi-tropical, semi-arid regions of mainly the Old World.
Cochrane, V., Press, M.C.
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