Results 71 to 80 of about 1,599,750 (302)

How Common are the Magellanic Clouds? [PDF]

open access: yes, 2011
We introduce a probabilistic approach to the problem of counting dwarf satellites around host galaxies in databases with limited redshift information.
Abazajian   +33 more
core   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

Chemical cues mediating aphid location by natural enemies

open access: yesEuropean Journal of Entomology, 2008
There is increasing evidence that chemical cues play a pivotal role in host selection by the natural enemies of aphids. We use Vinson's (1976) division of the host selection process into habitat location, host location and host acceptance for both ...
Eduardo HATANO   +3 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

The nuclear to host galaxy relation of high redshift quasars [PDF]

open access: yes, 2007
We present near-infrared imaging with ESO VLT+ISAAC of the host galaxies of low luminosity quasars in the redshift range 1 < z < 2, aimed at investigating the relationship between the nuclear and host galaxy luminosities at high redshift.
Aldo Treves   +10 more
core   +3 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Behavioral and Reproductive Response of White Pine Weevil (Pissodes strobi) to Resistant and Susceptible Sitka Spruce (Picea sitchensis)

open access: yesInsects, 2010
White pine weevil (Pissodes strobi, Peck.) is a native forest insect pest in the Pacific Northwest of North America that attacks species of spruce (Picea spp.) and pine (Pinus spp.).
Jeanne A. Robert, Jörg Bohlmann
doaj   +1 more source

Host selection through collective decision

open access: yesACM Transactions on Autonomous and Adaptive Systems, 2012
In this article, we present a collective decision-making framework inspired by biological swarms and capable of supporting the emergence of a consensus within a population of agents in the absence of environment-mediated communication (stigmergy). Instead, amplification is the result of the variation of a confidence index, stored in individual memory ...
Saffre, F, Simaitis, A
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A Parkes half-Jansky sample of GPS galaxies [PDF]

open access: yes, 2002
This paper describes the selection of a new southern/equatorial sample of Gigahertz Peaked Spectrum (GPS) radio galaxies, and subsequent optical CCD imaging and spectroscopic observations using the ESO 3.6m telescope.
Bremer, M. N.   +3 more
core   +3 more sources

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