Results 81 to 90 of about 508,470 (286)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Argulus coregoni (Crustacea: Branchiura: Argulidae) Parasitic on a Dark Chub Nipponocypris temminckii (Cypriniformes: Xenocyprididae) in a Stream, Central Japan, with a List of Its Known Hosts in East Asia

Species Diversity
An adult male specimen of Argulus coregoni Thorell, 1864 was collected from the body surface of a dark chub Nipponocypris temminckii (Temminck and Schlegel, 1846) at 15 m elevation in a small stream in central Japan.
Kazuya Nagasawa, Ryu Uchiyama, Ko Tomikawa   +2 more
doaj   +1 more source

Cross-feeding of bifidobacteria promotes intestinal homeostasis: a lifelong perspective on the host health

npj Biofilms and Microbiomes
Throughout the life span of a host, bifidobacteria have shown superior colonization and glycan abilities. Complex glycans, such as human milk oligosaccharides and plant glycans, that reach the colon are directly internalized by the transport system of ...
Meifang Xiao, Chuan Zhang, Hui Duan, Arjan Narbad, Jianxin Zhao, Wei Chen, Qixiao Zhai, Leilei Yu, Fengwei Tian   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Occurrence and Morphology of Argulus coregoni (Crustacea: Branchiura: Argulidae) on Three Species of Fishes in Three Orders (Acipenseriformes, Cypriniformes, and Salmoniformes) Reared at a Fish Hatchery in Central Japan

Species Diversity
Adults of both sexes of Argulus coregoni Thorell, 1864 were collected from the body surface of bester [a hybrid of beluga Huso huso (Linnaeus, 1758) × sterlet sturgeon H. ruthenus (Linnaeus, 1758)], common carp Cyprinus carpio Linnaeus, 1758, and rainbow
Kazuya Nagasawa, Shigeaki Gorie
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Impact of Scientific Lac Cultivation Training on Lac Economy – A Study in Jharkhand [PDF]

The study has reported the impact of training on lac growers in terms of host utilization, livelihood conditions and income and employment generation. The study is based on the data collected from randomly selected 500 lac growers (trained and untrained)
Pal, Govind
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

THE EFFECTS OF MULTINATIONAL ENTERPRISES INVESTMENT IN THE NONTRADED SECTOR OF DEVELOPING ECONOMIES [PDF]

This paper draws attention to the implications of multinational enterprises (MNEs) investment in the nontraded sector of a developing host country when their investment is characterized by the transmission of superior technology, but also draws on the ...
Abera Gelan
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source