Results 101 to 110 of about 433,979 (304)
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Hosts, Guests and Parasites in Helena Maria Viramontes' “The Cariboo Café”
Miscelánea: A Journal of English and American Studies, 2018 The correlation between immigrants and parasites is a common theme in political discourse. The nation-state assumes the role of a living organism that allows the entrance of an alien, a guest of sorts, who, in turn, endangers the wellbeing of the host ...
Jesús Benito Sánchez
doaj +1 more source
Community pressure for green behaviour [PDF]
, 2012 The desire to avoid rousing community hostility may encourage firms to behave in an environmentally responsible manner. It has been conjectured that such 'informal regulation' could effectively replace formal intervention in some settings, and usefully ...
Heyes, A., Kapur, Sandeep
core
Seeing red over black and white: popular and media representations of inter-racial relationships as precursors to racial violence [PDF]
, 2011 The recent murder in the UK of Anthony Walker attests to the lingering antipathy, indeed hostility, toward intimate inter-racial relationships, especially those involving black men and white women.
Arbery Glenn Cannon +14 more
core +1 more source
Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity
Molecular Oncology, EarlyView.Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek +2 more
wiley +1 more source
Sounds of Silence: Organisational trust and decisions to blow the whistle
SA Journal of Industrial Psychology, 2008 Whistleblowing is a form of pro-social behaviour that occurs when an employee reports organisational wrongdoing to an authority able to implement corrective action. While a number of social factors may infuence an employee’s decision to blow the whistle,
Elli Binikos
doaj +1 more source
The Impact of Intra-group Interaction on Identity and Action [PDF]
, 2013 The unifying theme of the chapters presented in this thesis is that intra-group interaction impacts on in-group identity content, and this content provides a foundation for social action and social behaviour.
Smith, Laura Grace Elizabeth
core
FEBS Open Bio, EarlyView.The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan +6 more
wiley +1 more source
Racial Harassment, Ethnic Concentration and Economic Conditions [PDF]
In this paper, we analyse the association between spatial concentration of ethnic minorities, and racial harassment. Ethnic concentration relates to racial harassment through at least three channels: hostility in attitudes of majority individuals that ...
Dustmann, Christian +2 more
core
FEBS Open Bio, EarlyView.Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani +7 more
wiley +1 more source