Results 41 to 50 of about 88,485 (243)
Brain Sciences, 2023 26RFa, also referred to as QRFP, is a hypothalamic neuropeptide mainly known for its role in the regulation of appetite and glucose metabolism. Its possible relevance to emotional regulation is largely unexplored.
Henning Værøy +5 more
doaj +1 more source
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
European Psychiatry, 2021 Introduction The presence of low-activity alleles of the MAOA gene increases the risk of hostility. Objectives To study the association of hostility with high and low-active variants of the MAOA gene in an open population of men 45-64 years ...
V. Gafarov +5 more
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Indirect aggression use and its experience in penitentiary incarceration [PDF]
ProbacjaIntroduction: Aim of the research presented in this article is investigation of indirect aggression among inmates. Indirect aggression covers aggressive behaviors toward social position and reputation of the victim, such as ridiculing, disseminating of ...
Krzysztof Nowakowski +1 more
doaj +1 more source
A STRANGER: PROJECTION OF ALIENATED FEMALE INDIVIDUALITY IN JEAN RHYS’S SHORT STORIES
Іноземна філологіяThe present study examines the prose texts written by Jean Rhys (1890–1979), a British woman writer of modernist literature. It is based on the perusal of several short stories, among others: “In the Rue de l’Arrivée”, “A Night”, “La Grosse Fifi ...
Nadiya Polishchuk
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Adaptation of the Malevolent Creativity Behavior Scale
Психологическая наука и образование, 2019 The paper presents results of adapting the Russian version of the Malevolent Creativity Behavior Scale (MCBS) developed under the guidance of M.Ranko (Hao et al, Front.Psychol.2016.Vol.7.682).The adaptation was carried out in 2016—2018 on a sample of 458
Meshkova N.V., +3 more
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source