Results 51 to 60 of about 43,927 (260)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Moralization and the 2012 U.S. Presidential Election Campaign
Journal of Social and Political Psychology, 2015 People vary in the extent to which they imbue an attitude with moral conviction; however, little is known about what makes an issue transform from a relatively non-moral preference to a moral conviction. In the context of the 2012 U.S.
Mark J. Brandt +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Malevolent Creativity of Adolescents in Different Socio-political Contexts
Национальный психологический журналBackground. Malevolent creativity is realized in interpersonal interaction in the form of bullying and unethical behavior, harming the psychological health of the victim.
Natalya V. Meshkova +4 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Nordic Journal of Migration Research, 2015 This study analyses the changing role of the family as a source of social capital in aiding migration, settlement and social integration of Zimbabwean migrants.
Chipo Hungwe
doaj +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Psychological factors of social anxiety in students
Консультативная психология и психотерапия, 2011 The study examined psychological factors of social anxiety in students in frames of multi-factor model of emotional disorders by A. Kholmogorova, N. Garanian, described methods and procedures of the research, presented correlations between the level of ...
Pavlova T.S., Kholmogorova A.B.
doaj
Self‐Managed Housing in Vienna: Managing Ambivalences Between “Invitability” and Resistance
Social InclusionThis contribution addresses how self‐managed collaborative housing (CoHo) groups engage in and with urban planning in Vienna and thereby how they manage the ambivalence of simultaneously getting involved in established planning and maintaining their ...
Andrea Schikowitz
doaj +1 more source
Aggression and Harm-Avoidant Trait Impede Recovery From Internet Gaming Disorder
Frontiers in Psychiatry, 2018 Background: Relatively little is known about which neuropsychological factors promote recovery from Internet gaming disorder (IGD).Methods: With informed consents, a cohort study was conducted in Seoul metropolitan area, South Korea, to investigate the ...
Seung-Yup Lee +5 more
doaj +1 more source