Results 71 to 80 of about 88,485 (243)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

Factors affecting the interrelationship between cynical hostility and dental anxiety among dental patients

open access: yesIndian Journal of Dental Research, 2019
Objectives: The objectives of this study were to assess the relationship between dental anxiety and cynical hostility in a sample of dental patients and to study the possible role of socioeconomic status (SES) in this relationship. Materials and Methods:
Shashidhar Acharya   +3 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

REPRESENTATION OF PSYCHOLOGICAL PROBLEMS IN KAREN HORNEY’S CHARACTEROLOGICAL ANALYSIS

open access: yesВестник Кемеровского государственного университета, 2016
The purpose of research is to establish K. Horney’s views on psychological problems, by means of theoretical analysis of literature. The term "psychological problem" is not mentioned by Karen Horney, however, she describes emotional, cognitive and ...
E. A. Sokolova
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Addressing Online Political Hostility

open access: yes, 2023
Social media inherently holds democratic potential, enabling anyone to access information, connect with others and discuss politics. Yet, behaviors that undermine democratic norms often plague political discussions on social media.
Jesper Rasmussen
core   +1 more source

Social-psychological Aspects of Bullying: Interconnection of Aggressiveness and School Anxiety

open access: yesПсихологическая наука и образование (2007. Online), 2017
Bullying is seen as a variant of aggression. Natural interconnections between contents of teenagers’ fears, anxiety and aggression are analyzed. The longitudinal research results are presented, in the framework of which four consecutive measures of ...
Tarasova S.Ju.   +2 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

open access: yesFEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Hosts, Guests and Parasites in Helena Maria Viramontes' “The Cariboo Café”

open access: yesMiscelánea: A Journal of English and American Studies, 2018
The correlation between immigrants and parasites is a common theme in political discourse. The nation-state assumes the role of a living organism that allows the entrance of an alien, a guest of sorts, who, in turn, endangers the wellbeing of the host ...
Jesús Benito Sánchez
doaj   +1 more source

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