Results 201 to 210 of about 6,351 (247)

Seafloor Displacements Across the Mid‐Ocean Ridge Eruption Cycle Modulated by Mush Zone Viscosity

Journal of Geophysical Research: Solid Earth, Volume 131, Issue 8, August 2026.
Abstract Mid‐ocean ridges (MORs) are active volcanic systems where axial magma lenses (AMLs) are replenished on decadal time scales, enabling frequent dike intrusions. The associated seafloor deformation, however, remains scarcely understood. Here we assess this deformation by simulating cycles of steady AML inflation followed by instantaneous dike ...
H. Boulze, J.‐A. Olive
wiley   +1 more source

Experimental Constraints on the Formation of Niningerite and Oldhamite Under Highly Reducing Conditions: Implications for Sulfide Formation in EH3 Chondrites

Journal of Geophysical Research: Planets, Volume 131, Issue 8, August 2026.
Abstract Enstatite chondrites record highly reducing conditions in the early solar nebula, yet the origin of their abundant sulfides remains unclear. Niningerite (MgS) and oldhamite (CaS) are ubiquitous in EH3 enstatite chondrites and distinguish them from other chondrite groups.
N. Imae
wiley   +1 more source

Rational Design, Synthesis, and Biological Evaluation of New Substituted Dihydropyrimidinones as Antibacterial Agents and β‐Lactamase Inhibitors

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
Novel 1,6‐dihydropyrimidinones act as antibacterial agents and beta‐lactamase inhibitors. Compounds 3d, 3i, and 7b demonstrated enhanced beta‐lactamase inhibition relative to the standard reference, clavulanic acid, demonstrating significant potentiation effects to restore antibiotic efficacy and combat resistant bacterial strains. ABSTRACT A series of
Ahmed M. Soliman, Heba Abdelrasheed Allam, Walaa R. Mahmoud, Bassem H. Naguib   +3 more
wiley   +1 more source

Formulation Development of Solid Self-Nanoemulsifying Drug Delivery Systems of Quetiapine Fumarate via Hot-Melt Extrusion Technology: Optimization Using Central Composite Design. [PDF]

Pharmaceutics
Uttreja P, Youssef AAA, Karnik I, Sanil K, Narala N, Wang H, Elkanayati RM, Vemula SK, Repka MA.   +8 more
europepmc   +1 more source

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Pharmaceutical Applications of Hot-Melt Extrusion: Part II

Drug Development and Industrial Pharmacy, 2007
Interest in hot-melt extrusion techniques for pharmaceutical applications is growing rapidly with well over 100 papers published in the pharmaceutical scientific literature in the last 12 years. Hot-melt extrusion (HME) has been a widely applied technique in the plastics industry and has been demonstrated recently to be a viable method to prepare ...
, Michael Repka, Sunil Kumar Battu
exaly   +4 more sources

Hot-melt extrusion microencapsulation of quercetin for taste-masking

Journal of Microencapsulation, 2017
Besides its poor dissolution rate, the bitterness of quercetin also poses a challenge for further development. Using carnauba wax, shellac or zein as the shell-forming excipient, this work aimed to microencapsulate quercetin by hot-melt extrusion for taste-masking.
Parijat Kanaujia, Yuancai Dong, Wai Kiong Ng   +2 more
exaly   +3 more sources

Hot-Melt Extrusion: a Roadmap for Product Development

AAPS PharmSciTech, 2021
Hot-melt extrusion has found extensive application as a feasible pharmaceutical technological option over recent years. HME applications include solubility enhancement, taste masking, and sustained drug release. As bioavailability enhancement is a hot topic of today's science, one of the main applications of HME is centered on amorphous solid ...
Marta F, Simões, Rui M A, Pinto, Sérgio, Simões   +2 more
openaire   +2 more sources

Hot Melt Extrusion: A Paradigm–Changing Technology

Recent Advances in Drug Delivery and Formulation, 2023
Abstract: Over the last few decades, hot melt extrusion (HME) has found extensive adaptability and utility as a viable drug delivery option in the pharmaceutical industry. HME has already been validated as a robust, novel technique mainly used for the correction of solubility and bioavailability of poorly soluble drugs.
Vaibhav G. Bhamare, Ravindra K. Kamble
openaire   +2 more sources

Hot melt extrusion versus spray drying: hot melt extrusion degrades albendazole

Drug Development and Industrial Pharmacy, 2016
The purpose of this study was to enhance the dissolution properties of albendazole (ABZ) by the use of amorphous solid dispersions. Phase diagrams of ABZ-polymer binary mixtures generated from Flory-Huggins theory were used to assess miscibility and processability.
Soraya, Hengsawas Surasarang, Justin M, Keen, Siyuan, Huang, Feng, Zhang, James W, McGinity, Robert O, Williams   +5 more
openaire   +2 more sources

Continuous Processing of Micropellets via Hot-Melt Extrusion

AAPS PharmSciTech, 2022
Microparticulate drug delivery systems, e.g., micropellets (MPs), are used in a variety of pharmaceutical formulations such as suspensions, injectable systems, and capsules. MPs are currently manufactured mainly via batch, solvent-based processes, e.g., spray-drying and solvent evaporation-extraction.
Martin Spoerk, Ioannis Koutsamanis, Andreas Kottlan, Christian Makert, Michael Piller, Manuel Rajkovaca, Amrit Paudel, Johannes Khinast   +7 more
openaire   +2 more sources