Results 241 to 250 of about 16,706 (282)

Hot melt extrusion versus spray drying: hot melt extrusion degrades albendazole

Drug Development and Industrial Pharmacy, 2016
The purpose of this study was to enhance the dissolution properties of albendazole (ABZ) by the use of amorphous solid dispersions. Phase diagrams of ABZ-polymer binary mixtures generated from Flory-Huggins theory were used to assess miscibility and processability.
Soraya, Hengsawas Surasarang, Justin M, Keen, Siyuan, Huang, Feng, Zhang, James W, McGinity, Robert O, Williams   +5 more
openaire   +2 more sources

Continuous Processing of Micropellets via Hot-Melt Extrusion

AAPS PharmSciTech, 2022
Microparticulate drug delivery systems, e.g., micropellets (MPs), are used in a variety of pharmaceutical formulations such as suspensions, injectable systems, and capsules. MPs are currently manufactured mainly via batch, solvent-based processes, e.g., spray-drying and solvent evaporation-extraction.
Martin Spoerk, Ioannis Koutsamanis, Andreas Kottlan, Christian Makert, Michael Piller, Manuel Rajkovaca, Amrit Paudel, Johannes Khinast   +7 more
openaire   +2 more sources

Hot-melt extrusion of sugar-starch-pellets

International Journal of Pharmaceutics, 2015
Sugar-starch-pellets (syn. sugar spheres) are usually manufactured through fluidized bed granulation or wet extrusion techniques. This paper introduces hot-melt extrusion (HME) as an alternative method to manufacture sugar-starch-pellets. A twin-screw extruder coupled with a Leistritz Micro Pelletizer (LMP) cutting machine was utilized for the ...
Chi-Wah, Yeung, Hubert, Rein
openaire   +2 more sources

Hot-melt Extrusion Technology and Pharmaceutical Application

Therapeutic Delivery, 2012
The use of hot-melt extrusion (HME) within the pharmaceutical industry is steadily increasing, due to its proven ability to efficiently manufacture novel products. The process has been utilized readily in the plastics industry for over a century and has been used to manufacture medical devices for several decades.
Wilson, M., Williams, M.A., Jones, D.S., Andrews, G.P.   +3 more
openaire   +3 more sources

Cocrystalization and Simultaneous Agglomeration Using Hot Melt Extrusion

Pharmaceutical Research, 2010
To explore hot melt extrusion (HME) as a scalable, solvent-free, continuous technology to design cocrystals in agglomerated form.Cocrystal agglomerates of ibuprofen and nicotinamide in 1:1 ratio were produced using HME at different barrel temperature profiles, screw speeds, and screw configurations.
Dhumal, Ravindra S., Kelly, Adrian L., York, Peter, Coates, Philip D., Paradkar, Anant R   +4 more
openaire   +4 more sources

Hot Melt Extrusion Technique-A Review

Research Journal of Science and Technology, 2016
Hot Melt Extrusion (HME) is well known process for the Plastic Industries but it is well accepted by the pharmaceutical industries for the last three decays. With the use of HME we can increase solubility and bio-availability of the API. HME has proven to be a robust method of producing numerous drug delivery systems like modified, controlled and ...
Bhushan A. Bhairav, Prajakta A. Kokane, Ravindra B. Saudagar   +2 more
openaire   +1 more source

Hot-melt extrusion.

Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti, 2012
Hot-melt extrusion (HME), originally coming from plastic industry, becomes at present an interesting technology also in the pharmaceutical field. The number of drugs with poor solubility and also bioavailability is increasing. In addition, most of the organic drugs are exhibiting polymorphism.
Salandová, Jana, Rabišková, Miloslava
openaire   +1 more source

Residence time modeling of hot melt extrusion processes

European Journal of Pharmaceutics and Biopharmaceutics, 2013
The hot melt extrusion process is a widespread technique to mix viscous melts. The residence time of material in the process frequently determines the product properties. An experimental setup and a corresponding mathematical model were developed to evaluate residence time and residence time distribution in twin screw extrusion processes. The extrusion
Elena, Reitz, Helmut, Podhaisky, David, Ely, Markus, Thommes   +3 more
openaire   +2 more sources

Hot-Melt Extrusion for Enhanced Delivery of Drug Particles

Journal of Pharmaceutical Sciences, 2007
With the recent advent of nanotechnology for pharmaceutical applications, drug particle engineering is the focus of increasing interest as a viable approach for overcoming solubility limitations of poorly water-soluble drugs. Although these particle engineering techniques have been proven successful for enhancing the dissolution properties of many ...
Dave A, Miller, Jason T, McConville, Wei, Yang, Robert O, Williams, James W, McGinity   +4 more
openaire   +2 more sources

Hot-melt extrusion microencapsulation of quercetin for taste-masking

Journal of Microencapsulation, 2017
Besides its poor dissolution rate, the bitterness of quercetin also poses a challenge for further development. Using carnauba wax, shellac or zein as the shell-forming excipient, this work aimed to microencapsulate quercetin by hot-melt extrusion for taste-masking.
Chia Miang, Khor, Wai Kiong, Ng, Parijat, Kanaujia, Kok Ping, Chan, Yuancai, Dong   +4 more
openaire   +2 more sources