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Applications of hot-melt extrusion for drug delivery [PDF]
Expert Opinion on Drug Delivery, 2008 In today's pharmaceutical arena, it is estimated that more than 40% of new chemical entities produced during drug discovery efforts exhibit poor solubility characteristics. However, over the last decade hot-melt extrusion (HME) has emerged as a powerful processing technology for drug delivery and has opened the door to a host of molecules previously ...
Michael A Repka +2 more
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Multi-scale reinforcements stimulated dynamic recrystallization and mechanical behavior of as-extruded titanium matrix composites [PDF]
MATEC Web of Conferences, 2020 Different volume fraction of TiB, TiC and La2O3 multiple-reinforced Ti6Al4V composites were fabricated by casting and followed by forging and hot extrusion.
Qiu Peikun +5 more
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Journal of Materials Research and Technology, 2023 Hot extrusion process can improve the mechanical properties of materials. However, due to the presence of SiC particles, SiCp/Al composites are prone to fracture damage in the extrusion process.
Mingyuan Zhang +4 more
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Optimization of hot extrusion process parameters for 7075 aluminum alloy rims based on HyperXtrude
Journal of Materials Research and Technology, 2023 Aluminum alloy has the characteristics of light weight, high strength, corrosion resistance, easy forming, etc., and is widely used in manufacturing industry.
Hongchao Ji +4 more
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Journal of Materials Research and Technology, 2023 Direct hot forging of heavily-alloyed Ni-based superalloy castings usually ends up with severe cracking due to serious macro-segregation. To address this issue, we propose to use hot extrusion as the replacement technology to process this kind of ...
Xingyu Pan +3 more
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Hot Extrusion of Ceramics [PDF]
Journal of the American Ceramic Society, 1992 Two dense ceramics, Bi 2 Sr 2 CaCu 2 O 8+ X and 2Y‐TZP: 10 wt% Al 2
Wu, Xin, Chen, I-Wei
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Simulation of Cross Wedge Rolling and Hot Extrusion-Combined Forming Process for Axle Sleeve
Metals, 2023 In this paper, an axle sleeve is formed through a combined cross wedge rolling (CWR) and hot extrusion process, and the combined forming process is simulated via finite element analysis software Deform-3D.
Wenhui Sun, Cuiping Yang
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Hot Melt Extrusion: Highlighting Physicochemical Factors to Be Investigated While Designing and Optimizing a Hot Melt Extrusion Process [PDF]
Pharmaceutics, 2018 Hot-melt extrusion (HME) is a well-accepted and extensively studied method for preparing numerous types of drug delivery systems and dosage forms. It offers several advantages: no solvents are required, it is easy to scale up and employ on the industrial level, and, in particular, it offers the possibility of improving drug bioavailability.
Roberta Censi +3 more
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International Journal of Lightweight Materials and Manufacture, 2022 Hot stretch bending (HSB) was an advanced manufacturing process for fuselage structure of aircraft. In this work, U shaped titanium extrusion hot stretch bending was investigated by applying numerical and experimental approaches. Hot uniaxial tension was
Baosheng Liu +3 more
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Chinese Journal of Mechanical Engineering, 2019 Compact hot extrusion (CHE) process of heavy caliber thick-wall pipe is a new material-saving production process. In order to reveal the optimum hot extrusion parameters in CHE process, the effects of the extrusion parameters on the microstructural ...
Lu Jia +3 more
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