Results 41 to 50 of about 808,635 (307)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Effect of strain state on the surface roughening for hydroforming of aluminum alloy tube based on cross-scale numerical modeling

Journal of Materials Research and Technology
The complex deformation behavior would result in surface roughening such as orange peel defect during the hydroforming process of aluminum alloy tubular parts.
Shiqiang Zhu, Wentao Chen, Jie Zhao, Shijian Yuan   +3 more
doaj   +1 more source

Development of technology for hot-drape forming of large torus sections [PDF]

, 1967
Compound-contoured sheet metal structure development is aided by hot-drape forming, a method combining hot-stretch forming, die quenching, and age forming.

core   +1 more source

Doppler shift of hot coronal lines in a moss area of an active region [PDF]

, 2012
The moss is the area at the footpoint of the hot (3 to 5 MK) loops forming the core of the active region where emission is believed to result from the heat flux conducted down to the transition region from the hot loops. Studying the variation of Doppler
Dadashi, Neda, Solanki, Sami K., Teriaca, Luca, Tripathi, Durgesh, Wiegelmann, Thomas   +4 more
core   +1 more source

Comparative experimental study of hot-formed, hot-finished and cold-formed rectangular hollow sections

Case Studies in Structural Engineering, 2016
AbstractThis paper presents a comparative experimental study on the physical, chemical and mechanical properties of indirectly formed hot-formed, hot-finished and cold-formed structural steel rectangular hollow sections. Characteristic geometrical parameters and chemical compositions are examined to investigate the physical and chemical differences ...
Zhang, Xing-Zhao, Liu, Su, Zhao, Ming-Shan, Chiew, Sing-Ping   +3 more
openaire   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Deformation behavior of anisotropic TA18 titanium alloy tube in hydroforming process at room temperature

Advances in Industrial and Manufacturing Engineering
While hydroforming of titanium alloy at room temperature is difficult due to its high strength, low hardening capacity, and significant springback, it is typically deformed into desired shape under high-temperature conditions exceeding 500°C, which ...
Xiao-Lei Cui, Yuanyang Zhao, Shijie Yin, Jiuqiang He   +3 more
doaj   +1 more source

Characterisation and modelling of the flow behaviour of a medium manganese steel for hot forming [PDF]

MATEC Web of Conferences
Medium manganese steels offer a wide range of advantages in hot forming compared to conventional boron steels such as lower heating temperatures and critical quenching rates.
Althaus Philipp, Rana Radhakanta, Wester Hendrik, Uhe Johanna, Behrens Bernd-Arno   +4 more
doaj   +1 more source

Method for forming plastic materials Patent [PDF]

, 1970
Hot forming of plastic ...
Naples, J. F.
core   +1 more source