Results 41 to 50 of about 807,470 (283)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Effect of strain state on the surface roughening for hydroforming of aluminum alloy tube based on cross-scale numerical modeling

Journal of Materials Research and Technology
The complex deformation behavior would result in surface roughening such as orange peel defect during the hydroforming process of aluminum alloy tubular parts.
Shiqiang Zhu, Wentao Chen, Jie Zhao, Shijian Yuan   +3 more
doaj   +1 more source

Method for forming plastic materials Patent [PDF]

, 1970
Hot forming of plastic ...
Naples, J. F.
core   +1 more source

Hot gas and dust in a protostellar cluster near W3(OH [PDF]

, 1999
We used the IRAM Interferometer to obtain sub-arcsecond resolution observations of the high-mass star-forming region W3(OH) and its surroundings at a frequency of 220 GHz.
Baudry A., C. Malcolm Walmsley, Friedrich Wyrowski, Helmich F. P., Karl M. Menten, Mauersberger R., Mauersberger R., Mezger P. G., Peter Schilke, Wink J. E., Wyrowski F.   +10 more
core   +2 more sources

Comparative experimental study of hot-formed, hot-finished and cold-formed rectangular hollow sections

Case Studies in Structural Engineering, 2016
AbstractThis paper presents a comparative experimental study on the physical, chemical and mechanical properties of indirectly formed hot-formed, hot-finished and cold-formed structural steel rectangular hollow sections. Characteristic geometrical parameters and chemical compositions are examined to investigate the physical and chemical differences ...
Zhang, Xing-Zhao, Liu, Su, Zhao, Ming-Shan, Chiew, Sing-Ping   +3 more
openaire   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Design Study for Automatic Production Line of a Sub-Assemblies of New Generation Car Body Structures Compliant with the “Industry 4.0” Concept

Sensors, 2021
A design study of automatic line-to-production of a new generation of car body structures compliant with the Industry 4.0 concept is described in this paper.
Ireneusz Wrobel, Marcin Sidzina
doaj   +1 more source

Deuterium burning in objects forming via the core accretion scenario - Brown dwarfs or planets?

, 2012
Aims. Our aim is to study deuterium burning in objects forming according to the core accretion scenario in the hot and cold start assumption and what minimum deuterium burning mass limit is found for these objects.
Mollière, Paul, Mordasini, Christoph
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Deformation behavior of anisotropic TA18 titanium alloy tube in hydroforming process at room temperature

Advances in Industrial and Manufacturing Engineering
While hydroforming of titanium alloy at room temperature is difficult due to its high strength, low hardening capacity, and significant springback, it is typically deformed into desired shape under high-temperature conditions exceeding 500°C, which ...
Xiao-Lei Cui, Yuanyang Zhao, Shijie Yin, Jiuqiang He   +3 more
doaj   +1 more source