Results 51 to 60 of about 1,607,359 (288)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Synergistic enhancement of strength and ductility in Mg–Gd–Y–Zn–Zr alloys through LPSO phases with multiple morphologies

Metals Advances
As a crucial strengthening phase in rare-earth magnesium alloys, the content and morphology of the long period stacking ordered (LPSO) phase significantly influence the mechanical properties of the alloys, yet the specific regulatory mechanisms and ...
Zeyu Zhao, Zhibin Chen, Hailong Shi, Jinhua Cao, Xuejian Li, Xiaoshi Hu, Xiaojun Wang, Weimin Gan, Xinghong Zhang   +8 more
doaj   +1 more source

Study on Hot Diaphragm Forming Process of CCF300/5228A Composites

MATEC Web of Conferences, 2017
In this paper, the hot diaphragm forming process of CCF300/5228A composite was studied through self-developed hot diaphragm forming equipment. CCF300/5228A prepreg for the hot diaphragm forming process was modified.
Yan Li, An Xuefeng
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Effect of strain state on the surface roughening for hydroforming of aluminum alloy tube based on cross-scale numerical modeling

Journal of Materials Research and Technology
The complex deformation behavior would result in surface roughening such as orange peel defect during the hydroforming process of aluminum alloy tubular parts.
Shiqiang Zhu, Wentao Chen, Jie Zhao, Shijian Yuan   +3 more
doaj   +1 more source

Control-Oriented Characterization of Product Properties during Hot Hole-Flanging of X46Cr13 Sheet Material in a Progressive-Die

Metals, 2021
Robust and versatile production is enabled by a closed-loop control of product properties. This essentially relies on the characterization of the interaction between properties and available degrees of freedom to control the process.
Juri Martschin, Rickmer Meya, Daniel Klöser, Thomas Meurer, A. Erman Tekkaya   +4 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Application of the microstructure development model to the multiscale fem simulation of metal forming processes [PDF]

Computer Methods in Materials Science, 2007
Models of recrystallization and grain growth mechanisms in hot forming processes are rarely implemented in the commercial finite element codes. However, most of the commercial packages give ability to implement additional modules for specific phenomena ...
Andrzej Żmudzki, Jarosław Nowak
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Deformation behavior of anisotropic TA18 titanium alloy tube in hydroforming process at room temperature

Advances in Industrial and Manufacturing Engineering
While hydroforming of titanium alloy at room temperature is difficult due to its high strength, low hardening capacity, and significant springback, it is typically deformed into desired shape under high-temperature conditions exceeding 500°C, which ...
Xiao-Lei Cui, Yuanyang Zhao, Shijie Yin, Jiuqiang He   +3 more
doaj   +1 more source