Results 41 to 50 of about 132,623 (257)

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Deformation behavior of anisotropic TA18 titanium alloy tube in hydroforming process at room temperature

Advances in Industrial and Manufacturing Engineering
While hydroforming of titanium alloy at room temperature is difficult due to its high strength, low hardening capacity, and significant springback, it is typically deformed into desired shape under high-temperature conditions exceeding 500°C, which ...
Xiao-Lei Cui, Yuanyang Zhao, Shijie Yin, Jiuqiang He   +3 more
doaj   +1 more source

Characterisation and modelling of the flow behaviour of a medium manganese steel for hot forming [PDF]

MATEC Web of Conferences
Medium manganese steels offer a wide range of advantages in hot forming compared to conventional boron steels such as lower heating temperatures and critical quenching rates.
Althaus Philipp, Rana Radhakanta, Wester Hendrik, Uhe Johanna, Behrens Bernd-Arno   +4 more
doaj   +1 more source

Control-Oriented Characterization of Product Properties during Hot Hole-Flanging of X46Cr13 Sheet Material in a Progressive-Die

Metals, 2021
Robust and versatile production is enabled by a closed-loop control of product properties. This essentially relies on the characterization of the interaction between properties and available degrees of freedom to control the process.
Juri Martschin, Rickmer Meya, Daniel Klöser, Thomas Meurer, A. Erman Tekkaya   +4 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

An Overview of Plastic Deformation Preparation Methods and Application of Gradient-Structured Materials

Journal of Manufacturing and Materials Processing
Gradient-structured materials have attracted considerable attention due to their gradient microstructural distribution and the resulting unique mechanical properties, showing great potential in aerospace, marine, and energy applications.
Zhenhai Xu, Jiajia Wang, Shaoxi Xue, Debin Shan, Jie Xu, Bin Guo   +5 more
doaj   +1 more source

Devising Strain Hardening Models Using Kocks–Mecking Plots—A Comparison of Model Development for Titanium Aluminides and Case Hardening Steel

Metals, 2016
The present study focuses on the development of strain hardening models taking into account the peculiarities of titanium aluminides. In comparison to steels, whose behavior has been studied extensively in the past, titanium aluminides possess a much ...
Markus Bambach, Irina Sizova, Sebastian Bolz, Sabine Weiß   +3 more
doaj   +1 more source

Study on Deformation Characteristics and Microstructure Evolution of 2205/AH36 Bimetal Composite in a Novel Hot Forming Process

Metals, 2020
A new hot forming process of a hot-rolled 2205 duplex stainless/AH36 low-carbon steel bimetal composite (2205/AH36 BC) was proposed in this study, using the Gleeble 3500 thermal-mechanical simulator and hot bending tools.
Zhou Li, Haibo Xie, Fanghui Jia, Yao Lu, Xiangqian Yuan, Sihai Jiao, Zhengyi Jiang   +6 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source