Results 41 to 50 of about 49,909 (286)
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Materials & DesignThe application of Au-based alloys in precision instruments components has achieved good results as electric contact materials. In order to investigate the hot processing of Au-based alloys, the hot deformation behavior and dynamic recrystallization (DRX)
Xiaoyi Pu +7 more
doaj +1 more source
Hot Deformation Behavior and Processing Maps of Fe-30Mn-0.11C Steel [PDF]
Materials, 2018 Hot deformation behavior of Fe-30Mn-0.11C steel was investigated. Hot compression tests were carried out at various temperatures ranging from 800 °C to 1200 °C and at different strain rates of 0.01 s−1 to 10 s−1. The constitutive equation based on peak stress was established.
Jianmei Kang +5 more
openaire +2 more sources
Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe
FEBS Open Bio, EarlyView.Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley +1 more source
Flow Behavior and Hot Processing Map of GH4698 for Isothermal Compression Process [PDF]
Processes, 2019 An in-depth understanding of the flow behaviors of materials deformed at high temperatures is of paramount significance. However, insufficient research on the nickel-based GH4698 alloy has resulted in inaccurate material flow prediction or even cracking in the practical billet opening of GH4698 large forgings.
Rongchuang Chen +3 more
openaire +1 more source
Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276
FEBS Open Bio, EarlyView.Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig +7 more
wiley +1 more source
Effect of temperature and strain rate on compressive response of extruded magnesium nano-composite
Journal of Magnesium and Alloys, 2015 The hot deformation behaviour of extruded magnesium-zinc oxide nano composite has been studied using hot compression test. The test was conducted in the temperature range of 250–400 °C and in the strain rate range of 0.01 to 1.5 s−1.The processing map ...
B. Selvam +5 more
doaj +1 more source
Journal of Magnesium and Alloys, 2023 The fundamental research on thermo-mechanical conditions provides an experimental basis for high-performance Mg-Al-Ca-Mn alloys. However, there is a lack of systematical investigation for this series alloys on the hot-deformation kinetics and extrusion ...
Qinghang Wang +7 more
doaj +1 more source
Characterization of Hot Workability in AISI 4340 Based on a 3D Processing Map [PDF]
, 2022 Joonhee Park +3 more
openalex +1 more source