Results 1 to 10 of about 331,533 (209)
Recent applications of computational methods to allosteric drug discovery
Frontiers in Molecular Biosciences, 2023 Interest in exploiting allosteric sites for the development of new therapeutics has grown considerably over the last two decades. The chief driving force behind the interest in allostery for drug discovery stems from the fact that in comparison to ...
Rajiv Gandhi Govindaraj +4 more
doaj +1 more source
Influence of thermal-mechanical stress on the insulation system of a low voltage electrical machine [PDF]
Archives of Electrical Engineering, 2021 Varying ohmic loss in the winding of electrical machines, which are operated at various operating points, results in temperature changes during operation.
Liguo Yang, Florian Pauli, Kay Hameyer
doaj +1 more source
Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers
Nature Communications, 2022 SMARCA2 has been identified as a synthetic lethal target in SMARCA4 mutated tumors, however, homology between the two has hindered the development of selective SMARCA2 inhibitors.
Jennifer Cantley +28 more
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Frontiers in Neurology, 2022 BackgroundIn recent years, there has been an increasing number of publications on Meniere's disease. However, there are no bibliometric research on Meniere's disease.
Wujun Zou +3 more
doaj +1 more source
Suicides on the Austrian railway network: hotspot analysis and effect of proximity to psychiatric institutions [PDF]
Royal Society Open Science, 2017 Railway suicide is a significant public health problem. In addition to the loss of lives, these suicides occur in public space, causing traumatization among train drivers and passengers, and significant public transport delays.
Markus J. Strauss +3 more
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Intraurban NO2 hotspot detection across multiple air quality products
Environmental Research Letters, 2023 High-resolution air quality data products have the potential to help quantify inequitable environmental exposures over space and across time by enabling the identification of hotspots, or areas that consistently experience elevated pollution levels ...
Anastasia Montgomery +6 more
doaj +1 more source
Diversity, 2023 The frequency of cetacean strandings is increasing, with multiple causes identified. We examined temporal and spatial trends in stranding numbers along the coastal areas of the East China Sea from 1990 to 2021.
Shaobo Yang +3 more
doaj +1 more source
Reset dynamics and latching in niobium superconducting nanowire single-photon detectors [PDF]
, 2010 We study the reset dynamics of niobium (Nb) superconducting nanowire single-photon detectors (SNSPDs) using experimental measurements and numerical simulations. The numerical simulations of the detection dynamics agree well with experimental measurements,
Alessandro Casaburi +12 more
core +2 more sources
Low-activity hotspot investigation method via scanning using deep learning
Frontiers in Energy Research, 2022 Small areas of elevated activity are a concern during a final status scan survey of residual radioactivity of decommissioned and contaminated sites.
Junwoo Bae +6 more
doaj +1 more source
Chandra Observations of the Radio Galaxy 3C 445 and the Hotspot X-ray Emission Mechanism [PDF]
, 2009 We present new {\it Chandra} observations of the radio galaxy 3C 445, centered on its southern radio hotspot. Our observations detect X-ray emission displaced upstream and to the west of the radio-optical hotspot.
Aloy +38 more
core +4 more sources