Results 51 to 60 of about 335,663 (313)

Post-translational Modification Crosstalk and Hotspots in Sirtuin Interactors Implicated in Cardiovascular Diseases

Frontiers in Genetics, 2020
Sirtuins are protein deacetylases that play a protective role in cardiovascular diseases (CVDs), as well as many other diseases. Absence of sirtuins can lead to hyperacetylation of both nuclear and mitochondrial proteins leading to metabolic ...
Suruchi Aggarwal, Suruchi Aggarwal, Suruchi Aggarwal, Sanjay K. Banerjee, Narayan Chandra Talukdar, Narayan Chandra Talukdar, Amit Kumar Yadav   +6 more
doaj   +1 more source

Pola Distribusi Spasial-Temporal Hotspot dan Variasi Standardized Precipitation Index pada Lahan Gambut Tropis di Kepulauan Meranti, Riau

Jurnal Ilmu Lingkungan, 2022
Kebakaran hutan dan lahan yang terjadi setiap tahun di Indonesia sebagian besar berlokasi di lahan gambut. Bencana tersebut berdampak besar terhadap berbagai aspek kehidupan, salah satunya adalah terdegradasinya lahan gambut tropis.
Maulana Dwi Putra Riyadi, Yudi Setiawan, Muh Taufik   +2 more
doaj   +1 more source

Offloading traffic hotspots using moving small cells

, 2016
In this paper, the concept of moving small cells in mobile networks is presented and evaluated taking into account the dynamics of the system. We consider a small cell moving according to a Manhattan mobility model which is the case when the small cell ...
Chahed, Tijani, Jaziri, Aymen, Nasri, Ridha   +2 more
core   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Recognizing hotspots in Brief Eclectic Psychotherapy for PTSD by text and audio mining

European Journal of Psychotraumatology, 2020
Background: Identifying and addressing hotspots is a key element of imaginal exposure in Brief Eclectic Psychotherapy for PTSD (BEPP). Research shows that treatment effectiveness is associated with focusing on these hotspots and that hotspot frequency ...
Sytske Wiegersma, Mirjam J. Nijdam, Arjan J. van Hessen, Khiet P. Truong, Bernard P. Veldkamp, Miranda Olff   +5 more
doaj   +1 more source

Imaging Transport Resonances in the Quantum Hall Effect [PDF]

, 2005
We use a scanning capacitance probe to image transport in the quantum Hall system. Applying a DC bias voltage to the tip induces a ring-shaped incompressible strip (IS) in the 2D electron system (2DES) that moves with the tip.
G. A. Steele, K. W. West, L. N. Pfeiffer, R. C. Ashoori, R. R. Prange   +4 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Efecto del precio de la vivienda en la geografía del robo en Querétaro, México: aplicación de procesos de puntos Poisson

Perspectiva Geográfica, 2023
En esta investigación se somete a prueba la teoría de las incivilidades para explicar la formación de hotspots de robo a casa habitación en la Zona Metropolitana de Querétaro.
Guillermo San Román Tajonar
doaj   +1 more source

The Far-Ultraviolet Spectrum and Short Timescale Variability of AM Herculis from Observations with the Hopkins Ultraviolet Telescope [PDF]

, 1998
Using the Hopkins Ultraviolet Telescope (HUT), we have obtained 850-1850 angstrom spectra of the magnetic cataclysmic variable star AM Her in the high state.
Beardmore A. P., Bradford W. Greeley, Cropper M. S., Davey S. C., Frank J., Gansicke B. T., Heise J., John C. Raymond, King A. R., Knox S. Long, Kuijpers J., Mukai K., Ramsay G., Southwell K. A., van Teeseling A., Wickramasinghe D. T., William P. Blair   +16 more
core   +3 more sources