Results 31 to 40 of about 101,606 (266)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Better-Weeds – Next generation weed management
Julius-Kühn-Archiv, 2022 Digitalisation in agriculture is currently expanding very rapidly. Digital field maps, geo-referenced machine movements, and a vast set of sensors on different platforms are already utilised on arable farms and even robotic field management is tested ...
Redwitz, Christoph von +9 more
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Hotspot analysis and prediction for mobile networking applications
Annals of TelecommunicationsUnderstanding the dynamics of mobile traffic is highly valuable for a variety of fields, such as transportation and networking. In particular, analyzing hotspots, i.e., areas presenting an increased popularity at certain times, is crucial for adequate planning and management operations. Yet, despite its importance, we lack today a precise definition of
Djuikom Foka, Gwladys Ornella +3 more
openaire +2 more sources
Spatial analysis to identify hotspots of prevalence of schizophrenia
Social Psychiatry and Psychiatric Epidemiology, 2008 The geographical distribution of mental health disorders is useful information for epidemiological research and health services planning.To determine the existence of geographical hotspots with a high prevalence of schizophrenia in a mental health area in Spain.The study included 774 patients with schizophrenia who were users of the community mental ...
Moreno Küstner, Berta +4 more
openaire +6 more sources
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Remote Sensing, 2022 Vietnam’s 3260 km coastline is densely populated, experiences rapid urban and economic growth, and faces at the same time a high risk of coastal hazards. Satellite archives provide a free and powerful opportunity for long-term area-wide monitoring of the
Ronja Lappe +2 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Wide Area Detection and Distribution Characteristics of Landslides along Sichuan Expressways
Remote Sensing, 2022 Wide area landslide detection is a major international research hotspot in the field of geological hazards, and the integration of multi-temporal optical satellite images and spaceborne interferometric synthetic aperture radar (InSAR) appears to be an ...
Bo Chen +13 more
doaj +1 more source
A U.S. Lead Exposure Hotspots Analysis
Environmental Science & TechnologyTo identify U.S. lead exposure risk hotspots, we expanded upon geospatial statistical methods from a published Michigan case study. The evaluation of identified hotspots using five lead indices, based on housing age and sociodemographic data, showed moderate-to-substantial agreement with state-identified higher-risk locations from nine public health ...
Valerie G. Zartarian +8 more
openaire +2 more sources