Results 51 to 60 of about 22,167,605 (308)

A U.S. Lead Exposure Hotspots Analysis

Environmental Science & Technology
To identify U.S. lead exposure risk hotspots, we expanded upon geospatial statistical methods from a published Michigan case study. The evaluation of identified hotspots using five lead indices, based on housing age and sociodemographic data, showed moderate-to-substantial agreement with state-identified higher-risk locations from nine public health ...
Valerie G. Zartarian, Jianping Xue, Antonios G. Poulakos, Rogelio Tornero-Velez, Lindsay W. Stanek, Emily Snyder, Veronica Helms Garrison, Kathryn Egan, Joseph G. Courtney   +8 more
openaire   +2 more sources

Characteristics of non-synonymous hotspot mutations for spatial analysis.

, 2022
Characteristics of non-synonymous hotspot mutations for spatial analysis.
Nimisha Ghosh (9637889), Indrajit Saha (1561636), Suman Nandi (475081)   +2 more
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

A comparative analysis of hotspot identification methods

Accident Analysis & Prevention, 2010
The identification of crash hotspots is the first step of the highway safety management process. Errors in hotspot identification may result in the inefficient use of resources for safety improvements and may reduce the global effectiveness of the safety management process. Despite the importance of using effective hotspot identification (HSID) methods,
openaire   +3 more sources

Virusplot: a web server for viral integration analysis and visualization

Frontiers in Oncology
The integration of viral DNA into the human genome is a critical event in the pathogenesis of various cancers. This process leads to genomic instability, disrupts cellular regulatory mechanisms, and activates oncogenes or inactivates tumor suppressor ...
Erqiang Hu, Erqiang Hu, Erqiang Hu, Jianhong An, Jianhong An, Jianhong An, Adam J Gersten, Adam J Gersten, Nicole Wu, Nicole Kawachi, Jing Zhu, Gregory Rosenblatt, Stelby Augustine, Richard V. Smith, Jeffrey E Segall, Harry Ostrer, Antonio L Amelio, Antonio L Amelio, Christine H. Chung, Michael B. Prystowsky, Thomas J. Ow, Thomas J. Ow, Wenjun Deng, Shanye Yin, Shanye Yin, Shanye Yin   +25 more
doaj   +1 more source

Pembangunan Spatiotemporal Data Model Pada Data Hotspot Dengan Konsep Event-based Spatiotemporal Data Model (ESTDM) [PDF]

, 2011
Hotspot data that has been existed all this time is still in the form of usual spatial data which is not enough to keep temporal information and information about how a hotspot evolved.
Kurniawan, Yuridhis
core  

Distribution maps of endemic Caspian Sea mollusks in hotspot and non-hotspot areas

, 2019
The Caspian Sea is renowned for its endemic mollusk biodiversity. However, over the past decades, increasing anthropogenic pressures have caused decreases in abundances and even extinction of species.
Lattuada, Matteo, Raes, Niels, Albrecht, Christian, Vinarski, Maxim V, Wesselingh, Frank P, Kijashko, Pavel, Klinkenbuß, Denise, Wilke, Thomas   +7 more
core   +1 more source

Characteristics of non-synonymous hotspot mutations for temporal analysis.

, 2022
Characteristics of non-synonymous hotspot mutations for temporal analysis.
Nimisha Ghosh (9637889), Indrajit Saha (1561636), Suman Nandi (475081)   +2 more
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source