Results 41 to 50 of about 101,606 (266)

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Regional Pathways to Internationalization: The Role of Erasmus+ in European HEIs

Urban Science
This study examines the geographic distribution of Erasmus+ incoming student mobility across European Higher Education Institutions (HEIs) from 2014 to 2020, highlighting significant regional disparities.
Eleni Georgoudaki, Spyridon Stavropoulos, Dimitris Skuras   +2 more
doaj   +1 more source

Improving the Understanding of Landslide Development in Alpine Forest Regions Using the InSAR Technique: A Case Study in Xiaojin County China

Applied Sciences, 2023
Employing a small baseline subset Interferometric Synthetic Aperture Radar (SBAS-InSAR) and hotspot analysis, this study identified 81 potential landslides in a 768.7 km2 area of Xiaojin county, eastern Tibetan Plateau. Subsequent time-series deformation
Shu Zhou, Zhen Guo, Gang Huang, Kanglin Liu   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Surveillance of COVID-19 Using Geospatial Data: An Emergency Department Perspective

Dubai Medical Journal, 2021
Background: The outbreak of coronavirus 2019 (COVID-19) which emerged in December 2019 spread rapidly and created a public health emergency. Geospatial records of case data are needed in real time to monitor and anticipate the spread of infection ...
S. Ashok, Malik Zaka Ullah, Nandakumar Vadivelu, Mohammed Tariqul Islam, Safa Nasereddin, Wajahat Zafar Khan   +5 more
doaj   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Bibliometric Analysis of Hotspots and Frontiers of Immunotherapy in Pancreatic Cancer

Healthcare, 2023
Background: Pancreatic cancer is one of the most common malignant neoplasms with an increasing incidence, low rate of early diagnosis, and high degree of malignancy. In recent years, immunotherapy has made remarkable achievements in various cancer types including pancreatic cancer, due to the long-lasting antitumor responses elicited in the human body.
Xu, Qiong, Zhou, Yan, Zhang, Heng, Li, Haipeng, Qin, Haoren, Wang, Hui   +5 more
openaire   +2 more sources

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Spatiotemporal Dynamics and Projections of Carbon Storage Using Integrated PLUS-InVEST Modeling: A Case Study of the Guanzhong Plain Urban Agglomeration, China

Land
Rapid urbanization has driven land-use transitions, leading to the continuous replacement of land-use types with high carbon storage capacity by those with lower capacity.
Zhongzhen Zhu, Yuxi Yang, Yixin Zhang, Ling Qiu, Tian Gao   +4 more
doaj   +1 more source