Results 21 to 30 of about 1,180,320 (210)

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Identification and Ranking of Binding Sites from Structural Ensembles: Application to SARS-CoV-2

Viruses
Target identification and evaluation is a critical step in the drug discovery process. Although time-intensive and complex, the challenge becomes even more acute in the realm of infectious disease, where the rapid emergence of new viruses, the swift ...
Maria Lazou, Ayse A. Bekar-Cesaretli, Sandor Vajda, Diane Joseph-McCarthy   +3 more
doaj   +1 more source

Novel major QTLs associated with low soil phosphorus tolerance identified from the Indian rice landrace, Wazuhophek.

PLoS ONE, 2021
With an objective of mapping novel low soil P (Phosphorus) tolerance loci in the non-Pup1 type donor rice line, Wazuhophek, we screened a recombinant inbred line (RIL) mapping population consisting of 330 lines derived from the cross Wazuhophek x ...
Ravindra Ramrao Kale, Ch V Durga Rani, M Anila, H K Mahadeva Swamy, V P Bhadana, P Senguttuvel, D Subrahmanyam, M Ayyappa Dass, K Swapnil, M S Anantha, E Punniakotti, B Laxmi Prasanna, G Rekha, P Sinha, M B V N Kousik, T Dilip, S K Hajira, P Brajendra, S K Mangrauthia, C Gireesh, Mangaldeep Tuti, R Mahendrakumar, Jitendra Giri, Pawandeep Singh, R M Sundaram   +24 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Human–Tiger Conflict in and Around Chitwan–Parsa National Parks: Status, Trends, Contributing Factors, Mitigation Strategies, and Community Perceptions

Ecology and Evolution
Human casualties are among the most severe consequences of human–tiger conflict (HTC), and recent evidence from Nepal indicates an increasing trend in tiger‐related incidents.
Aayush Shrestha, Narendra Man Babu Pradhan, Naresh Subedi, Bikram Shrestha, Divesh Shrestha, Mahesh Neupane, Krishna Prasad Dahal   +6 more
doaj   +1 more source

Chromosome-Wide Characterization of Intragenic Crossover in Shiitake Mushroom, Lentinula edodes

Journal of Fungi, 2021
Meiotic crossover plays a critical role in generating genetic variations and is a central component of breeding. However, our understanding of crossover in mushroom-forming fungi is limited. Here, in Lentinula edodes, we characterized the chromosome-wide
Wenbing Gong, Nan Shen, Lin Zhang, Yinbing Bian, Yang Xiao   +4 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

De Novo Protein Design Enables Targeting of Intractable Oncogenic Protein–Protein Interfaces

Biologics
Background/Objectives: Protein–protein interactions (PPIs) involving oncogenic drivers remain among the most intractable targets in cancer biology due to their dynamic conformations and limited accessibility to conventional small molecules.
Varshika Ram Prakash, Yusuf Najy, Kalel Garrett, Brian F. P. Edwards, Benjamin L. Kidder   +4 more
doaj   +1 more source

REVIEW OF 3D GIS DATA FUSION METHODS AND PROGRESS [PDF]

ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2018
3D data fusion is a research hotspot in the field of computer vision and fine mapping, and plays an important role in fine measurement, risk monitoring, data display and other processes.
W. Hua, M. Hou, M. Hou, M. Hou, Y. Hu, Y. Hu, Y. Hu   +6 more
doaj   +1 more source