Results 31 to 40 of about 1,180,320 (210)

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Harnessing Technology for Vector-Borne Disease Control in Desert Terrain: Experiences from a Frontier Station

Medical Journal of Dr. D.Y. Patil Vidyapeeth
Introduction: Malaria is a major vector-borne disease in many parts of the world. The elimination of vector breeding sites remains a significant challenge in malaria control programs. The World Health Organisation (WHO) marked World Malaria Day 2022 with
Anand Neelakantan, V. S. Srikanth, B. M. John, Sameer Prabhakar   +3 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Spatio-temporal crime prediction and hotspot analysis in Addis Ababa, Ethiopia: a machine learning and geospatial approach

Cogent Social Sciences
Urban crime remains a major challenge in rapidly expanding cities, affecting public safety, economic development, and social stability. Yet crime prediction research remains concentrated in Western cities with strong data infrastructures, leaving rapidly
Esubalew Mulugeta Engda, Ziyen Achamyeleh Mekonnen, Tsegaye Ayele Tadesse, Mohammed Abegaz Adem, Ephrem Tega Teka, Kanenus Fufa Dararo, Talema Moged Reda, Muralitharan Jothimani   +7 more
doaj   +1 more source

Histone H3 Lysine 56 Acetylation Is Required for Formation of Normal Levels of Meiotic DNA Breaks in S. cerevisiae

Frontiers in Cell and Developmental Biology, 2020
Meiotic recombination is initiated by Spo11-catalyzed DNA double-strand breaks (DSBs) that are promoted by histone modifications and histone modifying enzymes. Herein we investigated the role of histone H3 lysine 56 acetylation (H3K56ac) located near the
Zsolt Karányi, Zsolt Karányi, Lilla Hornyák, Lóránt Székvölgyi   +3 more
doaj   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

A Workflow to Accelerate Microstructure‐Sensitive Fatigue Life Predictions

Advanced Engineering Materials, EarlyView.
This study introduces a workflow to accelerate predictions of microstructure‐sensitive fatigue life. Results from frameworks with varying levels of simplification are benchmarked against published reference results. The analysis reveals a trade‐off between accuracy and model complexity, offering researchers a practical guide for selecting the optimal ...
Luca Loiodice, Krzysztof S. Stopka, Michael D. Sangid   +2 more
wiley   +1 more source

Resilient Multi-UAV Collaborative Mapping: A Safety-Prioritized Scheduling Framework with Hierarchical Transmission

Drones
Multi-UAV collaborative mapping in communication-constrained indoor environments is often hampered by a trade-off between overall map refinement and the timely completion of safety-relevant shared regions.
Shu Wake, Zewei Jing, Lanxiang Hou, Jiayi Sun, Guanchong Niu, Liang Mao, Jie Li   +6 more
doaj   +1 more source

Endemism-based butterfly conservation: insights from a study in Southern Western Ghats, India

Journal of Basic and Applied Zoology, 2021
Background The Western Ghats, a biodiversity hotspot in India harbours a high percentage of endemic species due to its unique and diverse habitats. These species which cannot survive elsewhere due to their specialised habitat requirements are at high ...
M. Anto, C. F. Binoy, Ignatious Anto
doaj   +1 more source