Results 31 to 40 of about 26,802 (257)

Mapping trabecular disconnection “hotspots” in aged human spine and hip [PDF]

Bone, 2015
Trabecular bone disconnection is an independent factor in age-related skeletal failure where real termini (ReTm; rare in youth) may cause weakness disproportionate to tissue loss, yet their structural contribution at vulnerable locations remains uncertain.
Aaron, JE, Shore, PA, Itoda, M, Morrison, RJM, Hartopp, A, Hensor, EMA, Hordon, LD   +6 more
openaire   +3 more sources

A Crime Prediction Model/Tool for Hotspot Mapping

International Journal of Advanced Research in Science, Communication and Technology, 2023
The hotspot map is a popular analytics tool used to help law enforcement and crime reduction resources determine where to focus. Essentially, the hotspot map is used as a data-driven crime map to identify high-crime areas and places where police and other criminal activities should be used. The project uses crime data from a period before (already past)
null Sabin T T, null Archana R, null Lithisha K J, null Vikhyath P   +3 more
openaire   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Histone H3 Lysine 56 Acetylation Is Required for Formation of Normal Levels of Meiotic DNA Breaks in S. cerevisiae

Frontiers in Cell and Developmental Biology, 2020
Meiotic recombination is initiated by Spo11-catalyzed DNA double-strand breaks (DSBs) that are promoted by histone modifications and histone modifying enzymes. Herein we investigated the role of histone H3 lysine 56 acetylation (H3K56ac) located near the
Zsolt Karányi, Zsolt Karányi, Lilla Hornyák, Lóránt Székvölgyi   +3 more
doaj   +1 more source

A model of knowledge mapping in visualizing the hotspot of dengue [PDF]

2011 IEEE Conference on Open Systems, 2011
Formulation process is very important in model development. Due to that, this study was performed as a formulation process for the K-Map model development in order to visualize the dengue hotspot. Purpose of this study is to find the appropriate technique on knowledge visualization and also to identify the contributing parameters for the dengue ...
Az-Azira Abdul Aziz, Rusli Abdullah, Hamidah Ibrahim   +2 more
openaire   +1 more source

KNOWLEDGE MAP, HOTSPOTS AND FRONTIERS OF ECOLOGICAL INNOVATION

2021 International Conference on Education, Humanity and Language, Art (EHLA 2021), 2021
China is facing the "ecological deficit" caused by environmental pollution and shortage of energy resources. Ecological innovation, as the integration point of innovation-driven development strategy and sustainable development strategy, provides a feasible path for achieving a win-win situation for the economy, society and the environment. Based on the
TENG-FEI LIU, CHENG-LIN FAN
openaire   +2 more sources

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Crime Hotspot Detection and Monitoring Using Video Based Event Modeling and Mapping Techniques*

International Journal of Computational Intelligence Systems, 2017
This paper presents a new approach to crime hotspot detection and monitoring. The approach consists of three phases’ namely: video analysis, crime prediction and crime mapping.
Zou Beiji, Nurudeen Mohammed, Zhu Chengzhang, Zhao Rongchang   +3 more
doaj   +1 more source