Results 31 to 40 of about 27,015 (256)

Identification and Ranking of Binding Sites from Structural Ensembles: Application to SARS-CoV-2

Viruses
Target identification and evaluation is a critical step in the drug discovery process. Although time-intensive and complex, the challenge becomes even more acute in the realm of infectious disease, where the rapid emergence of new viruses, the swift ...
Maria Lazou, Ayse A. Bekar-Cesaretli, Sandor Vajda, Diane Joseph-McCarthy   +3 more
doaj   +1 more source

Chromosome-Wide Characterization of Intragenic Crossover in Shiitake Mushroom, Lentinula edodes

Journal of Fungi, 2021
Meiotic crossover plays a critical role in generating genetic variations and is a central component of breeding. However, our understanding of crossover in mushroom-forming fungi is limited. Here, in Lentinula edodes, we characterized the chromosome-wide
Wenbing Gong, Nan Shen, Lin Zhang, Yinbing Bian, Yang Xiao   +4 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Human–Tiger Conflict in and Around Chitwan–Parsa National Parks: Status, Trends, Contributing Factors, Mitigation Strategies, and Community Perceptions

Ecology and Evolution
Human casualties are among the most severe consequences of human–tiger conflict (HTC), and recent evidence from Nepal indicates an increasing trend in tiger‐related incidents.
Aayush Shrestha, Narendra Man Babu Pradhan, Naresh Subedi, Bikram Shrestha, Divesh Shrestha, Mahesh Neupane, Krishna Prasad Dahal   +6 more
doaj   +1 more source

REVIEW OF 3D GIS DATA FUSION METHODS AND PROGRESS [PDF]

ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2018
3D data fusion is a research hotspot in the field of computer vision and fine mapping, and plays an important role in fine measurement, risk monitoring, data display and other processes.
W. Hua, M. Hou, M. Hou, M. Hou, Y. Hu, Y. Hu, Y. Hu   +6 more
doaj   +1 more source

A model of knowledge mapping in visualizing the hotspot of dengue [PDF]

2011 IEEE Conference on Open Systems, 2011
Formulation process is very important in model development. Due to that, this study was performed as a formulation process for the K-Map model development in order to visualize the dengue hotspot. Purpose of this study is to find the appropriate technique on knowledge visualization and also to identify the contributing parameters for the dengue ...
Az-Azira Abdul Aziz, Rusli Abdullah, Hamidah Ibrahim   +2 more
openaire   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

KNOWLEDGE MAP, HOTSPOTS AND FRONTIERS OF ECOLOGICAL INNOVATION

2021 International Conference on Education, Humanity and Language, Art (EHLA 2021), 2021
China is facing the "ecological deficit" caused by environmental pollution and shortage of energy resources. Ecological innovation, as the integration point of innovation-driven development strategy and sustainable development strategy, provides a feasible path for achieving a win-win situation for the economy, society and the environment. Based on the
TENG-FEI LIU, CHENG-LIN FAN
openaire   +2 more sources

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Harnessing Technology for Vector-Borne Disease Control in Desert Terrain: Experiences from a Frontier Station

Medical Journal of Dr. D.Y. Patil Vidyapeeth
Introduction: Malaria is a major vector-borne disease in many parts of the world. The elimination of vector breeding sites remains a significant challenge in malaria control programs. The World Health Organisation (WHO) marked World Malaria Day 2022 with
Anand Neelakantan, V. S. Srikanth, B. M. John, Sameer Prabhakar   +3 more
doaj   +1 more source