Results 61 to 70 of about 85,194 (289)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Mapping agrobiodiversity in Europe: Different indicators, different priority areas
Ecological Indicators, 2023 Agriculture plays a dual role in the conservation of European biodiversity, as extensive agricultural lands provide habitats for more than half of Europe's species, but intensification and abandonment of farmland threaten these species' habitats ...
Antonia E. Matthies +3 more
doaj +1 more source
Multi-layer virtual transport network design [PDF]
, 2017 Service overlay networks and network virtualization enable multiple overlay/virtual networks to run over a common physical network infrastructure.
Matta, Ibrahim, Wang, Yuefeng
core +2 more sources
KNOWLEDGE MAP, HOTSPOTS AND FRONTIERS OF ECOLOGICAL INNOVATION
2021 International Conference on Education, Humanity and Language, Art (EHLA 2021), 2021 China is facing the "ecological deficit" caused by environmental pollution and shortage of energy resources. Ecological innovation, as the integration point of innovation-driven development strategy and sustainable development strategy, provides a feasible path for achieving a win-win situation for the economy, society and the environment. Based on the
TENG-FEI LIU, CHENG-LIN FAN
openaire +2 more sources
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Fokus auf der Untersuchung des Einflusses biometrischer Faktoren auf das Ergebnis der nTMS Messung sprachrelevanter Areale neurochirurgischer Patienten [PDF]
, 2019 Objective: Navigated transcranial magnetic stimulation (nTMS) is a non-invasive mapping tool to locate functional areas of the brain, gaining importance as a preoperative diagnostic device. This is a summary of three studies, Schwarzer et al., Rosenstock
Schwarzer, Vera
core +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Spatio-Temporal Sentiment Hotspot Detection Using Geotagged Photos
, 2016 We perform spatio-temporal analysis of public sentiment using geotagged photo collections. We develop a deep learning-based classifier that predicts the emotion conveyed by an image. This allows us to associate sentiment with place.
Ekman P. +4 more
core +1 more source
Global Hotspots of Conflict Risk between Food Security and Biodiversity Conservation [PDF]
, 2017 This work contributes to the Belmont Forum/FACCE-JPI DEVIL project (grant number NE/M021327/1), and AM is supported by a BBSRC EastBio Studentship (http://www.eastscotbiodtp.ac.uk/).
Dawson, Terence P +3 more
core +2 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source