Results 91 to 100 of about 6,400,597 (307)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Equality and Non-discrimination (EQND) in Sanitation Programmes at Scale (Part 1) [PDF]
, 2017 A well-facilitated Community-Led Total Sanitation (CLTS) programme that pro-actively considers and involves people who might be disadvantaged has been shown to have many benefits.
Sarah House, Sue Cavill, Suzanne Ferron
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Viabilità relazionale: una prospettiva im/mobile delle relazioni nel Gambia transnazionale
EtnoAntropologiaWhile anthropologists have long studied how mobility and immobility shape social relationships, this article describes relatedness itself as a form of im/mobility.
Paolo Gaibazzi
doaj
Adverse Selection and the Accelerator [PDF]
This paper reexamines the relationship between financial market imperfections and economic instability. I present a model in which financial accelerator effects come from adverse selection in credit markets.
Christopher L. House
core
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Dr. House: medical ethics and subjective responsibility
Revista de Medicina y Cine / Journal of Medicine and Movies, 2016 House’s first season premiered in November, 2004 and ended in 2012. Millions of people have enjoyed these 8 seasons over nearly a decade. Different conjectures have been put forward to try to explain the magnitude of the show’s success, giving way to ...
Elizabeth Beatriz ORMAT +1 more
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