Results 81 to 90 of about 2,385,256 (313)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Devenir un « maître de maison » dans le Sud jordanien

open access: yesAteliers d'Anthropologie, 2015
How does one become a master of the house, a man capable of controlling a kinship network and a family space? This article approaches the logic of power and authority in a tribal area of southern Jordan through its spatial and corporeal dimensions.
Christine Jungen
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

UNA CURIOSA FORMA ELEMENTAL DE ARQUITECTURA PIONERA RURAL EN MAGALLANES A CURIOUS ELEMENTAL FORM OF RURAL PIONEER ARCHITECTURE IN MAGALLANES

open access: yesMagallania, 2009
Se informa sobre el hallazgo de una forma arquitectónica elemental para uso como vivienda rural ocasional.The finding of an elemental architectonic form for use as occasional rural house is informed.
MATEO MARTINIC B
doaj  

L. N. Tolstoy on the 20th-Century Estate: From the “Civilization of Machines” to a New Natural House of the Eastern Type [PDF]

open access: yesДва века русской классики
The article is devoted to the image of the estate and the house in L. N. Tolstoy’s legacy, especially in his later works. The research indicates that at the turn of the century and in the first decade of the 20th century, Tolstoy became an ardent ...
Valeria G. Andreeva
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Extension of a Royal House: Servants of the Last Trastámara. The Infants of Castile and Aragon (1470-1504)

open access: yesRoyal Studies Journal, 2023
  The reign of the Catholic Monarchs is possibly the most important reign and, therefore, the most studied in the history of our country. However, this reign had a defect in the form of its offspring, not because of the absence of children but because ...
Oscar Jimenez Molero   +1 more
doaj  

Whittier House membership card for Anthony Trudzinski. Nationality is listed as "German-Polish."

open access: yes, 1939
This collection of Whittier House Boy's Club membership cards records children's names, parent's names, places of birth, nationalities, family members, occupations, church affiliations, and addresses.
Whittier House Boys Club
core   +1 more source

Home - About - Disclaimer - Privacy