Results 81 to 90 of about 6,400,597 (307)

Presidential Succession Act of 2007 [PDF]

open access: yes, 2007
A proposed bill that modifies the presidential succession list to include, following the Secretary of Homeland Security, the Ambassador to the United Nations, the Ambassador to Great Britain, the Ambassador to Russia, the Ambassador to China, and the ...
United States. House of Representatives
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Extension of a Royal House: Servants of the Last Trastámara. The Infants of Castile and Aragon (1470-1504)

open access: yesRoyal Studies Journal, 2023
  The reign of the Catholic Monarchs is possibly the most important reign and, therefore, the most studied in the history of our country. However, this reign had a defect in the form of its offspring, not because of the absence of children but because ...
Oscar Jimenez Molero   +1 more
doaj  

L. N. Tolstoy on the 20th-Century Estate: From the “Civilization of Machines” to a New Natural House of the Eastern Type [PDF]

open access: yesДва века русской классики
The article is devoted to the image of the estate and the house in L. N. Tolstoy’s legacy, especially in his later works. The research indicates that at the turn of the century and in the first decade of the 20th century, Tolstoy became an ardent ...
Valeria G. Andreeva
doaj   +1 more source

A more representative chamber: representation and the House of Lords [PDF]

open access: yes, 2012
Since 1997 there has been substantive reform of the House of Lords in an effort to make the chamber ‘more democratic and more representative’. Whilst the Labour government failed to press ahead with any of the proposed plans for further reform following ...
Andrew Defty   +11 more
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

UNA CURIOSA FORMA ELEMENTAL DE ARQUITECTURA PIONERA RURAL EN MAGALLANES A CURIOUS ELEMENTAL FORM OF RURAL PIONEER ARCHITECTURE IN MAGALLANES

open access: yesMagallania, 2009
Se informa sobre el hallazgo de una forma arquitectónica elemental para uso como vivienda rural ocasional.The finding of an elemental architectonic form for use as occasional rural house is informed.
MATEO MARTINIC B
doaj  

ISSUES, ALTERNATIVES AND CONSEQUENCES [PDF]

open access: yes
Agricultural and Food Policy,
House, Verne W.
core   +1 more source

Illinois Lo-Cal House [PDF]

open access: yes, 1976
The increasing scarcity of fuels makes it imperativeto include more energy conservation features in our housing. This circular describes the design, construction, and predicted performance of a house that uses approximately one-third of the energy needed
Jones, Rudard A., Shick, Wayne L.
core  

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

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