Results 31 to 40 of about 44,235 (254)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Influenţa jurisprudenţei europene asupra cadrului autohton al măsurilor preventive//The influence of european jurisprudence regarding criminal preventive measures

Analele Ştiinţifice ale Universităţii "Al.I. Cuza" din Iaşi. Ştiinţe Juridice
In judicial practice, criminal preventive measures attract attention that could be used for better purposes, moving away from their complementary role in per se criminal proceedings and deepening the sensitive border crack between private and societal ...
Bogdan TROFIN, Alexandru Cristian ADOCHIŢEI   +1 more
doaj   +1 more source

Functional connectivity explains how neuronavigated TMS of posterior temporal subregions differentially affect language processing

Brain Stimulation, 2023
Background: “Wernicke's area” is most often used to describe the posterior superior temporal gyrus (STG) and refers to a region traditionally thought to support language comprehension.
Maria Vasileiadi, Anna-Lisa Schuler, Michael Woletz, David Linhardt, Christian Windischberger, Martin Tik   +5 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Home Confinement in the United States: The Evolution of Progressive Criminal Justice Reform

Trento Student Law Review, 2020
Home confinement, also known as house arrest or home detention, first appeared in the United States in the 1970s as a form of pretrial release issued after a defendant's indictment.
Markus Aloyan
doaj  

Mulheres-mães selecionadas pelo sistema penal: os desafios do cuidado em prisão domiciliar

Sortuz, 2022
Este estudo busca responder quais desafios particulares mulheres-mães em prisão domiciliar enfrentam para viabilizar o cuidado de suas crianças. Partindo da sociologia do cuidado, o artigo apresenta o cuidado como componente do bem-estar social e como um
Amanda Kovalczuk de Oliveira Garcia, Jessica de Jesus Mota   +1 more
doaj  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

مدى شرعية تدبير الإقامة الجبرية في التشريع السوداني- دراسة مقارنة [PDF]

مجلة کلیة الشریعة والقانون بأسیوط
منذ استقلال السودان ظل مصطلح الإقامة الجبرية متداولاٌ وظل أكثر تداوله في الإطار السياسي وخاصة ما بعد مجيء حكم  نظام الإنقاذ عام 1989م ، ومنذ قيام ثوة ديسمبر المجيدة  2019م كثُر استخدام هذا المصطلح وظل متداولاٌ في الألسن دون إلمام الغالبية بمعناه ومن أين ...
شهاب سليمان عثمان, بابكر الصائم   +1 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source