Results 41 to 50 of about 2,088,465 (256)
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Home Confinement in the United States: The Evolution of Progressive Criminal Justice Reform
Trento Student Law Review, 2020 Home confinement, also known as house arrest or home detention, first appeared in the United States in the 1970s as a form of pretrial release issued after a defendant's indictment.
Markus Aloyan
doaj
Mulheres-mães selecionadas pelo sistema penal: os desafios do cuidado em prisão domiciliar
Sortuz, 2022 Este estudo busca responder quais desafios particulares mulheres-mães em prisão domiciliar enfrentam para viabilizar o cuidado de suas crianças. Partindo da sociologia do cuidado, o artigo apresenta o cuidado como componente do bem-estar social e como um
Amanda Kovalczuk de Oliveira Garcia +1 more
doaj
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
مدى شرعية تدبير الإقامة الجبرية في التشريع السوداني- دراسة مقارنة [PDF]
مجلة کلیة الشریعة والقانون بأسیوطمنذ استقلال السودان ظل مصطلح الإقامة الجبرية متداولاٌ وظل أكثر تداوله في الإطار السياسي وخاصة ما بعد مجيء حكم نظام الإنقاذ عام 1989م ، ومنذ قيام ثوة ديسمبر المجيدة 2019م كثُر استخدام هذا المصطلح وظل متداولاٌ في الألسن دون إلمام الغالبية بمعناه ومن أين ...
شهاب سليمان عثمان +1 more
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Alternative Sanctions in the Spanish Criminal Law [PDF]
Societas et Iurisprudentia, 2017 The paper is mainly focused on alternative sanctions that are amended in the Spanish criminal law. We think that the Slovak criminal law is not very different in developing alternative sanctions as the Spanish criminal law and this is the main reason why
Gustáv Dianiška +2 more
doaj
House arrest punishment, its execution and control
, 2023 House arrest punishment, its execution and control Abstract This diploma thesis deals with the punishment of house arrest as an alternative to imprisonment and its enforcement and control.
Balík, Tomáš
core
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source