Results 51 to 60 of about 419,416 (300)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Alternative Sanctions in the Spanish Criminal Law [PDF]

open access: yesSocietas et Iurisprudentia, 2017
The paper is mainly focused on alternative sanctions that are amended in the Spanish criminal law. We think that the Slovak criminal law is not very different in developing alternative sanctions as the Spanish criminal law and this is the main reason why
Gustáv Dianiška   +2 more
doaj  

Take the Money and Run: Detainment Incident to a Search Warrant in Bailey v. United States [PDF]

open access: yes, 2013
This commentary previews an upcoming Supreme Court case, Bailey v. United States, in which the Court will examine the scope of permissible non-arrest seizures in the context of a detainment incident to a search warrant.
Hall, Alexander
core   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

open access: yesFEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura   +19 more
wiley   +1 more source

Удосконалення практики застосування й виконання покарання у виді арешту шляхом внесення змін до КК України

open access: yesПроблеми Законності, 2013
Проаналізовано основні проблеми Кримінального кодексу України (2001 р.) в аспекті вдосконалення практики застосування та виконання покарання у виді арешту. Запропоновано нові редакції статей 391, 392, 393 закону.
К. А. Автухов
doaj   +1 more source

Representing the riots: the (mis)use of statistics to sustain ideological explanation [PDF]

open access: yes, 2012
This paper analyses the way that figures were used to support two kinds of accounts of the riots of August 2011 prevalent in media coverage and in pronouncements by government ministers.
Ball, Roger, Drury, John
core  

GAD65 Antibody ELISA With Extended Reportable Range: Validation and Guidance for Neurological Practice

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon   +11 more
wiley   +1 more source

Immigration Detainers, Local Discretion, and State Law\u27s Historical Constraints [PDF]

open access: yes, 2019
This thesis is an effort to investigate the operation and the performanceof modular multilevel converters (M2Cs). Proven to be the most promisingtopology in high-voltage high-power applications, it is necessary to put aneffort in understanding the ...
Evans, Kate
core   +2 more sources

On the issue of legal regulation of house arrest

open access: yesIus Publicum et Privatum, 2022
В статье анализируются нормы уголовно-процессуального законодательства, регулирующие порядок применения домашнего ареста. В частности, рассматриваются сущность, порядок, условия избрания данной меры пресечения. Уделяется внимание вопросам установления дополнительных запретов и ограничений при избрании меры пресечения, зачету срока исполнения домашнего ...
openaire   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu   +21 more
wiley   +1 more source

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