Results 101 to 110 of about 2,754,124 (316)

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Majority Leadership in the House of Representatives

Political Science Quarterly, 1980
In 1967 Randall Ripley, in a major work on House leadership, noted changes in this century that had weakened the legislative hold of House leaders on party members, in particular reduced resources, greater committee autonomy, and the growing power of seniority.' Paradoxically, despite major reforms of the House in the 1970s that increased leadership ...
openaire   +2 more sources

Political Limits to the Processing of Policy Problems

Politics and Governance, 2013
This contribution addresses political limits to the processing of policy problems in the United States. Our foci are the forces that limit policymakers' attention to different aspects of problems and how this affects the prospects for problem resolution.
Peter J. May, Ashley E. Jochim, Barry Pump   +2 more
doaj   +1 more source

Activit{é} motrice des truies en groupes dans les diff{é}rents syst{è}mes de logement [PDF]

arXiv, 2018
Assessment of the motor activity of group-housed sows in commercial farms. The objective of this study was to specify the level of motor activity of pregnant sows housed in groups in different housing systems. Eleven commercial farms were selected for this study.
arxiv  

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

ANALISIS YURIDIS PUTUSAN MAHKAMAH KONSTITUSI NOMOR 16/PUU-XVI/2018 TENTANG PEMBATALAN PERLUASAN KEWENANGAN MAHKAMAH KEHORMATAN DEWAN

Masalah-Masalah Hukum, 2019
This research analyzes the Constitutional Court Decision Number 16/PUU-XVI/2018 that has been canceled Article 122 letter l and Article 245 section (1) from the Law Number 2 of 2018.
Yohanes Nafta Irawan, Retno Saraswati, Esmi Warassih Pujirahayu   +2 more
doaj   +1 more source

Integration and Contagion in US Housing Markets [PDF]

arXiv, 2011
This paper explores integration and contagion among US metropolitan housing markets. The analysis applies Federal Housing Finance Agency (FHFA) house price repeat sales indexes from 384 metropolitan areas to estimate a multi-factor model of U.S. housing market integration. It then identifies statistical jumps in metropolitan house price returns as well
arxiv  

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

The Dispersion of Authority in the House of Representatives

Political Science Quarterly, 1982
Since its publication in 1968, congressional scholars have considered Nelson Polsby's article on "The Institutionalization of the U.S. House of Representatives" to be a singularly useful overview of the historical development of the House. ' Polsby demonstrated that during the twentieth century, the House had become increasingly "bounded" in its ...
openaire   +2 more sources