Results 101 to 110 of about 1,131,712 (326)

Immigration Policy and the Plight of Unskilled Workers [PDF]

open access: yes, 1999
Public testimony by Prof. Briggs given before the Subcommittee on Immigration and Claims of the Committee on the Judiciary, House of Representatives, March 11 ...
Briggs, Vernon M., Jr.
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

RWU Professor June Speakman Sworn into Rhode Island House of Representatives [PDF]

open access: yes, 2019
Roger Williams University Professor of Political Science June Speakman was sworn in to the Rhode Island House of Representatives by Attorney General Peter F.
Rubin, Julia
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Measuring Poverty in America [PDF]

open access: yes, 2007
Written Statement Submitted to the Subcommittee on Income Security and Family Support Committee on Ways and Means U.S.
Amy Rynell
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dewan Perwakilan Daerah Menurut UUD 1945 Dan Penerapan Sistem Bikameral Dalam Lembaga Perwakilan Indonesia [PDF]

open access: yes, 2007
Formally, Indonesia adopts bicameral system as there are the House of Representatives (DPR) and the Regional Representatives Council (DPD). However, structurally, it could be deemed ad tricameral, as there are three representative bodies available ...
Bardjo, B. (Bardjo)
core  

Shaheen Leads Poorly Known Republican Challengers in 2020 NH Senate Race 3/2/2020 [PDF]

open access: yes, 2020
Senator Jeanne Shaheen holds clear leads over prospective Republican challengers Former New Hampshire House of Representatives Speaker Bill O\u27Brien, Retired General Don Bolduc, and Attorney Corky Messner.
UNH Survey Center
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

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