Results 141 to 150 of about 1,364,174 (311)

Diabetes mellitus auto-referido no Município de São Paulo: prevalência e desigualdade

Cadernos de Saúde Pública
Constitui objetivo do presente trabalho a caracterização da prevalência do Diabetes Mellitus Auto-Referido (DMAR) no Município de São Paulo, obtida a partir do inquérito domiciliar realizado pelo Estudo Multicêntrico sobre a Prevalência do Diabetes no ...
Paulete Goldenberg, Laércio J. Franco, Heloisa Pagliaro, Rebeca de S. Silva, Carla A. dos Santos   +4 more
doaj  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Bounding Expected Per Capita Household Consumption in the Presence of Demographic Change [PDF]

This paper deals with the measurement of per capita household consumption expenditures when the household's underlying demographic structure changes during the survey period.
Timothy Halliday
core  

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

SAVE Household Recruitment Survey

, 2014
Survey used as part of the SAVE project recruitment process which is aiming to recruit c 4,200 households across the Solent region for a study of electricity demand. In addition to the survey households will also be asked to install (or have installed) electricity monitoring equipment.
Anderson, Ben, Lys, Coleman
openaire   +1 more source

The Survey on Health, Aging and Wealth [PDF]

Until very recently, health information has been mostly absent from Italian surveys of household budgets and economic conditions. Interest in the association between health outcomes, economic resources and labor market conditions has led us to fill the ...
Agar Brugiavini, Guglielmo Weber, Tullio Jappelli   +2 more
core  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Household Size Economies: Malaysian Evidence [PDF]

People live in households with different size and composition and they consume a variety of goods; categorised as private and public goods. With the existence of public goods in the household, doubling the household size need not increase the consumption
Gillis Maclean, Paul Dalziel, Thaiyoong Penny Mok   +2 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source