Results 191 to 200 of about 1,360,924 (312)

Morbidity and health seeking behavior among children and adolescents (0-19 years): a household survey assessment in Northwestern Tanzania. [PDF]

BMC Health Serv Res
Kagoye S, Todd J, Marston M, Urassa M, Konje ET, Boerma T.   +5 more
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Sexual and reproductive health service use of unmarried adolescents in Morogoro, Tanzania: insights from a cross-sectional household survey. [PDF]

Front Reprod Health
Morris BM, Chombo S, Ulrich CM, Kakoko DCV.   +3 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Use of tobacco and nicotine products among adolescents in Sub-Saharan Africa: protocol for a population-based multi-country household survey. [PDF]

Front Public Health
Kisia L, Mohamed SF, Kyule G, Tchoupé C, Abolarin O, Pokothoane R, Gelibo T, Iddi S, Okumu B, Mbaya N, Kadengye DT, Mirindi DM, Akiode A, Ademola T, Okezie U, Mdege ND.   +15 more
europepmc   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

SARS-CoV-2 seroprevalence and COVID-19 vaccination coverage in two states of Nigeria from a population based household survey. [PDF]

Sci Rep
Enyereibe NW, Ilori E, Steinhardt L, Stafford K, Dan-Nwafor C, Ochu CL, Ibrahim D, Alagi M, Ibrahim BS, Iwara IE, Mba N, Ibrahim Z, Ahmed RA, Botson I, Ogbonna SU, Igumbor E, Abubakar J, Ahmed N, Nwiyi GO, Ihemeje CE, Okoi C, John D, Ashikeni M, Muhammad BL, Iriemenam NC, Okunoye O, Greby SM, Bassey O, Okoye M, Blanco N, Mitchell A, Ipadeola O, Antonza GS, Mpamugo A, Makava F, Charurat M, Adebajo S, Swaminathan M, Ifedayo A, Ihekweazu C.   +39 more
europepmc   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Incidence, Impact, and Healthcare-Seeking Behavior for Extremity Fractures in Resource-Limited Settings: A Household Survey in Rural Tanzania. [PDF]

World J Surg
Binnerts JJ, Hendriks TCC, Okoth J, Gill-Wiehl A, Ranganathan K, Ehsan AN, Harun NW, Ogoya S, Bempong-Ahun N, Ibbotson G, Harrison WJ, Martin C, Edwards MJR, Hermans E, Chirangi BM.   +14 more
europepmc   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source