Results 81 to 90 of about 3,653,103 (356)

Effects of single housing on behavior, corticosterone level and body weight in male and female mice

Laboratory Animal Research
Experimental mice are often single-housed either for an individual analysis (feeding behavior, imaging, calorimetry) or as a stress paradigm (social isolation) in translational biomedical research.
I. Smolensky, K. Zajac-Bakri, A. Mallien, Peter Gass, R. Guzman, D. Inta   +5 more
semanticscholar   +1 more source

Housing microbial symbionts: evolutionary origins and diversification of symbiotic organs in animals

Philosophical Transactions of the Royal Society of London. Biological Sciences, 2020
In many animal hosts, microbial symbionts are housed within specialized structures known as symbiotic organs, but the evolutionary origins of these structures have rarely been investigated. Here, I adopt an evolutionary developmental (evo-devo) approach,
A. Douglas
semanticscholar   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Mutilating Procedures, Management Practices, and Housing Conditions That May Affect the Welfare of Farm Animals: Implications for Welfare Research

Animals, 2017
A number of mutilating procedures, such as dehorning in cattle and goats and beak trimming in laying hens, are common in farm animal husbandry systems in an attempt to prevent or solve problems, such as injuries from horns or feather pecking.
Rebecca E. Nordquist, Franz Josef van der Staay, Frank J. C. M. van Eerdenburg, Francisca C. Velkers, Lisa Fijn, Saskia S. Arndt   +5 more
doaj   +1 more source

Epidemiological study concerning the characteristics of organic pig farming in selected European countries [PDF]

, 2011
Interviews and on-farm assessments were conducted in a total of 101 organic pig farms in different European countries (Austria, Denmark, France, Germany, Italy, and Sweden) to gain knowledge about farm management and health status of organic pigs in ...
Bochicchio, Davide, Bonde, Marianne, Bourgoin, Aude, Cartaud, Gerald, Dietze, Klaas, Dippel, Sabine, Goebel, Amke, Gunnarsson, Stefan, Hegelund, Lene, Leeb, Christine, Lindgren, Kristina, Lubac, Stanislas, Prunier, Armelle, Sundrum, Albert, Wiberg, Sofia   +14 more
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Influence of light-exposure during late incubation and early feeding on the performance of layer chicks in a multitasking test and step detour test

Poultry Science
During on-farm hatching, chicken embryos experience continuous light during late incubation, and have immediate access to feed and water post-hatch. While on-farm hatching compared to hatchery-hatching improves several welfare indicators in broilers, the
Catharina M.H. Broekmeulen, Sabine G. Gebhardt-Henrich, Yamenah Gómez, Michael J. Toscano   +3 more
doaj   +1 more source

Hereditary hydrocephalus internus in a laboratory strain of golden hamsters (Mesocricetus auratus)

Animal, 2008
Golden hamsters of one common laboratory strain had a high incidence of hydrocephalus internus. When a severity score of hydrocephalus was used, a major autosomal recessive locus could be identified.
S.G. Gebhardt-Henrich, J.F. Edwards, T.R. Famula, H.-P. Lipp, A. Steiger   +4 more
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Evaluation of different types of enrichment - their usage and effect on home cage behavior in female mice.

PLoS ONE, 2021
Numerous studies ascertained positive effects of enriched environments on the well-being of laboratory animals including behavioral, physiological and neurochemical parameters.
Ute Hobbiesiefken, Paul Mieske, Lars Lewejohann, Kai Diederich   +3 more
doaj   +1 more source