Results 41 to 50 of about 354,081 (244)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Evaluation of Fire Hazard and Safety Management of Heritage Buildings in Georgetown, Penang

MATEC Web of Conferences, 2014
Fire is a subject that is always neglected and ignored as far as heritage buildings are concerned. Unlike newly-built buildings, which are required under UBBL to undergo certain fire protection system tests, people are less likely to carry out such tests
Othuman Mydin M.A., Sani N. Md, Abas N.F., Khaw Y.Y.   +3 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Determining the Compressive, Flexural and Splitting Tensile Strength of Silica Fume Reinforced Lightweight Foamed Concrete

MATEC Web of Conferences, 2014
This study investigated the performance of the properties of foamed concrete in replacing volumes of cement of 10%, 15% and 20% by weight. A control unit of foamed concrete mixture made with ordinary Portland cement (OPC) and 10%, 15% and 20% silica fume
Mydin M.A.O., Sani N. Md., Mohd Yusoff M.A., Ganesan S.   +3 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

A community-based health assessment among residents of affordable housing in San Francisco’s Hunters Point

Discover Public Health
We conducted a community-based participatory health assessment in San Francisco’s Hunters Point Hill neighborhood, led by a community-based affordable housing organization in partnership with academic public health researchers.
Lucia E. Calderon, Taylor Booker, Sharron Watts, David Sobel, Mitch Mankin, Amy Rich, Alison K. Cohen   +6 more
doaj   +1 more source

GREEN SITE MANAGEMENT PRACTICES IN THE MALAYSIAN CONSTRUCTION SITES

International Journal of Management Studies
This study intends to explore the available green site management practices for construction stakeholders. Green site management practices have been introduced to the construction industry to mitigate the negative impacts of construction activities if ...
Terh Jing Khoo , Mohd Wira Mohd Shafiei, Chin Yee Ha, Radzi Ismail   +3 more
doaj   +1 more source

Laboratory Investigation on Compressive Strength and Micro-structural Features of Foamed Concrete with Addition of Wood Ash and Silica Fume as a Cement Replacement

MATEC Web of Conferences, 2014
Wood Ash (WA) and Silica Fume (SF) exhibit good cementation properties and have great potential as supplementary binder materials for the concrete production industry.
Othuman Mydin M.A., Mohamed Shajahan M.F., Ganesan S., Sani N. Md.   +3 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Analysis of Rainwater Quality and Temperature Reduction Effects Using Rainwater Harvesting Facilities

Buildings
As eco-friendly complexes develop, interest in eco-friendly facilities is also growing. Particularly, rainwater harvesting facilities have demonstrated positive effects by reducing runoff to mitigate urban flooding and recycling water for landscaping and
JongSoo Choi, JungMin Lee, MyeongIn Kim, JaeHyeon Lee, YoungTae Cho   +4 more
doaj   +1 more source