Results 91 to 100 of about 44,748 (258)

Epigenetic Regulation of Liver Fibrosis: Mechanisms and Therapeutic Implications

Portal Hypertension &Cirrhosis, EarlyView.
This review synthesizes the epigenetic mechanisms—DNA methylation, histone modifications, and non‐coding RNAs—that drive hepatic stellate cell activation and the progression of liver fibrosis. It further evaluates emerging therapeutic strategies targeting these epigenetic regulators, including DNA methyltransferase and histone deacetylase inhibitors ...
Maryam Jadid Tavaf, Mahboobeh Ebrahimi Varkiani, Saeid Abroun, Pedram Asadi‐Sarabi, Shukoofeh Torabi, Elham Rismani, Mohammad Majd Hammour, Andreas K. Nüssler, Massoud Vosough   +8 more
wiley   +1 more source

Hox genes are not always Colinear

International Journal of Biological Sciences, 2006
The deuterostomes are the clade of animals for which we have the most detailed understanding of Hox cluster organisation. With the Hox cluster of amphioxus (Branchiostoma floridae) we have the best prototypical, least derived Hox cluster for the group ...
Ana Sara Monteiro, David E.K. Ferrier
doaj  

Online Versus Face‐to‐Face Multiparty Interactions: Effects on Emergent System Dynamics and Integrative Outcomes

Systems Research and Behavioral Science, EarlyView.
ABSTRACT Multiparty systems address wicked problems by bringing together stakeholders with diverse and sometimes competing interests. Although previous research has emphasized the role of expected positive interdependence in driving system‐level dynamics and reaching integrative negotiations, the impact of the communication environment (online versus ...
Elena Cristina Manole, Petru Lucian Curșeu, Sabina Ramona Trif, Sandra G. L. Schruijer   +3 more
wiley   +1 more source

Evaluating Thiram‐Induced Embryotoxicity Using Integrated In Silico, In Vitro, and Transcriptomic Approaches

Environmental Toxicology, EarlyView.
ABSTRACT Long‐term exposure to low‐dose food contact materials (FCMs) has raised concerns regarding developmental toxicity. In the present study, we prioritized FCMs with potential developmental toxicity using a weight‐of‐evidence computational model, which predicted 127 chemicals to be of high concern.
Chia‐Chi Ho, Chun‐Wei Tung, B. Linju Yen, Chen‐Yi Weng, Ju‐Hsin Hsu, Ming‐Hsien Tsai, Salim Arrokhman, Pinpin Lin   +7 more
wiley   +1 more source

Hox Gene Variation Drives Morphological Specialization of Humpback Grouper Cromileptes altivelis

Integrative Zoology, EarlyView.
Cromileptes altivelis exhibits a distinctive “sunken head and humpback” morphology, formed through cranial remodeling. Genetic analyses identified unique amino acid variants in Hoxa7a and Hoxa10b, with functional tests confirming their role in enhancing osteoblast activity and driving cranial remodeling.
Xiaoying Cao, Zhaowei Zhong, Lisheng Wu, Quanyin Liu, Shaoxiong Ding   +4 more
wiley   +1 more source

Regulation of HOX gene expression in AML

Blood Cancer Journal
As key developmental regulators, HOX cluster genes have varied and context-specific roles in normal and malignant hematopoiesis. A complex interaction of transcription factors, epigenetic regulators, long non-coding RNAs and chromatin structural changes ...
Irum Khan, Mohammed A. Amin, Elizabeth A. Eklund, Andrei L. Gartel   +3 more
doaj   +1 more source

More of the Same Makes a Difference: Comparative Anatomy and Molecular Makeup of Tenrec and Hedgehog Intestines

Integrative Zoology, EarlyView.
Tenrecs and hedgehogs have gastrointestinal tracts of comparable morphology, yet with marked differences in length. Among mammals, intestinal length is correlated with diet; however, these species share a common trophic niche. The length differences are accounted for by an expansion of the small intestine in the European hedgehog.
María J. Duque‐Correa, Antoine Fages, Eva Dervas, Athanasia C. Tzika, Maria J. Minguer‐Balderas, Charlotte E. T. Huyghe, Walter Salzburger, Patrick Tschopp, Marcus Clauss   +8 more
wiley   +1 more source

No more than 14: the end of the amphioxus Hox cluster

International Journal of Biological Sciences, 2005
The Hox gene cluster has been a key paradigm for a generation of developmental and evolutionary biologists. Since its discovery in the mid-1980's, the identification, genomic organization, expression, colinearity, and regulation of Hox genes have been ...
doaj  

The Hox-4.8 gene is localized at the 5' extremity of the Hox-4 complex and is expressed in the most posterior parts of the body during development

We report the isolation and expression pattern of a novel mouse homeobox gene, Hox-4.8. Hox-4.8 is the most 5'-located homeobox gene in the HOX-4 complex.
Izpisua-Belmonte, J. C., Boncinelli, E., Duboule, D., Dolle, P.   +3 more
core   +1 more source

Surgical Management of Non‐Allergic Rhinitis—An EAACI Task Force Position Paper

Allergy, EarlyView.
ABSTRACT Non‐allergic rhinitis is a frequent yet underdiagnosed cause of chronic nasal symptoms, including nasal congestion, rhinorrhoea, and upper airway hyperreactivity. Its pathophysiology involves neurogenic dysregulation, leading to excessive mucus production and vasodilation.
Marie Lundberg, Julie van Waterschoot, Mathilde Moyaert, Adam Chaker, Philippe Gevaert, Jan Hagemann, Valérie Hox, Maarten Kleijwegt, Ludger Klimek, Devyani Lal, Juan Maza‐Solano, Oliver Pfaar, Fabio Simon Ryser, Michele Shiappoli, Diana Silva, Sanna Toppila‐Salmi, Johanna Wikstén, Sietze Reitsma, Laura Van Gerven   +18 more
wiley   +1 more source