Results 61 to 70 of about 956,443 (283)
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
Analytical Determination of Ochratoxin A in Brewed and Green Coffee Beans by High-Performance Liquid Chromatography – Fluorescent Detector Method [PDF]
Iranian Journal of Chemistry & Chemical EngineeringCoffee contamination by Ochratoxin A (OTA) is becoming the main global emerging threat to its quality. The main objective of this study was to determine the levels of Ochratoxin A in coffee beans and brewed coffee samples.
Abiyot Kelecha +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
Determination of technological parametrs and good quality of phyto-tea based on medicinal peony (Paeonia officinalis l.) [PDF]
BIO Web of ConferencesPlants of the genus Paeonia are considered promising sources of natural sedatives. Primarily, roots and rhizomes are used as medicinal raw materials for the treatment of neurasthenia, neurosis, hypochondria, and insomnia.
Zuparova Zulfia +5 more
doaj +1 more source
Toxicological Analysis of Some Drugs of Abuse in Biological Samples [PDF]
, 2015 Consumption of drugs of abuse is a scourge of modern world. Abuse, drug addiction and their consequences are one of the major current problems of European society because of the significant repercussions in individual, family, social and economic level ...
Baconi, Daniela Luiza +5 more
core +3 more sources
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
Nano Biomedicine and Engineering, 2011 The pharmacokinetic profile of freeze-dried cyclosporine A-Eudragit S100 nanoparticles (CyA-S100-NP)was studied with a random two-way crossover study in dogs.
Yang Liu +5 more
doaj +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Examination of the optical purity of voriconazole on the brush-type stationary phase [PDF]
Kragujevac Journal of ScienceThe purpose of this research is to develop an HPLC method for determining the content of voriconazole enantiomers in powder for solution for infusion. Chromatographic analysis was conducted using a brush-type (Pirkle-type) stationary phase with isocratic
Turković Nemanja M. +3 more
doaj +1 more source
Advanced Engineering Materials, EarlyView.The release of foulers from protective marine coatings is determined by several interrelated material properties, including the strength of Young's modulus, the flexibility of chain segments, the surface free energy, and the magnitude of hydrodynamic stress.
Johann C. Schaal +2 more
wiley +1 more source