Results 111 to 120 of about 23,630,409 (308)

HPLC-MS/MS pooled samples

, 2018
HPLC-MS/MS runs of pooled MeOH extracts from Philanthus, Trachyous and Philanthunus specimen antennae and ...
Kai, Marco, Johannes Kroiss (82327), Aleš Svatoš (411268), Engl, Tobias, Svatoš, Aleš, Kaltenpoth, Martin, Martin Kaltenpoth (82326), Marco Kai (411264), Kroiss, Johannes, Nechitaylo, Taras Y., Taras Y. Nechitaylo (8033432), Tobias Engl (6259)   +11 more
core   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

HPLC-MS data of plant extracts and PARAFAC-based algorythm

, 2019
This dataset is uploaded as supplementary material for article "A new PARAFAC-based algorithm for HPLC-MS data treatment: Herbal extracts ...
Polina Turova (7412354)
core   +1 more source

Targeted Restoration of the Microbial Tryptophan Oxidative Pathway Ameliorates Autism‐Like Behavioral and Synaptic Deficits

Advanced Science, EarlyView.
ABSTRACT Autism Spectrum Disorder (ASD) is associated with gut microbiota dysbiosis, yet the contribution of specific microbial metabolic pathways remains unclear. Reanalysis of a public ASD cohort revealed reduced functional potential in microbial tryptophan oxidative metabolism.
Rui Guo, Caian He, Xiao Xiao, Jingmeng Li, Zilong Zhang, Ying He, Chuanchuan Wang, Jiale Zhao, Jun Gong, Jiarui Liang, Tian Yuan, Haiting Sun, Xuebo Liu, Chao Gao, Zhigang Liu   +14 more
wiley   +1 more source

HPLC-MS/MS Philanthus gibbosus cocoons

, 2018
HPLC-MS/MS runs of MeOH extracts from single Philanthus gibbosus cocoons reared in ...
Kai, Marco, Johannes Kroiss (82327), Aleš Svatoš (411268), Engl, Tobias, Svatoš, Aleš, Kaltenpoth, Martin, Martin Kaltenpoth (82326), Marco Kai (411264), Kroiss, Johannes, Nechitaylo, Taras Y., Taras Y. Nechitaylo (8033432), Tobias Engl (6259)   +11 more
core   +1 more source

Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer

Advanced Science, EarlyView.
The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu, Chong Wu, Shiyao Song, Li Ma, Shaoqing Huang, Yuting He, Qinghai Li, Yanzhou Chang, Dan Jiang, Yong Mei, Junchao Cai, Zhenshuang Du, Tianfeng Chen, Weiling He   +13 more
wiley   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Analysis of the endogenous human serum peptides by on-line extraction with restricted-access material and HPLC-MSMS identification

, 2014
Analysis of the endogenous human serum peptides by on-line extraction with restricted-access material and HPLC-MSMS ...
叶明亮, Karl-SiegfriedBoos, 邹汉法, 胡良海   +3 more
core  

HPLC-MS/MS Philanthus spp. Turkey

, 2018
HPLC-MS/MS runs of MeOH extracts of single Philanthus specimen antennae from ...
Kai, Marco, Johannes Kroiss (82327), Aleš Svatoš (411268), Engl, Tobias, Svatoš, Aleš, Kaltenpoth, Martin, Martin Kaltenpoth (82326), Marco Kai (411264), Kroiss, Johannes, Nechitaylo, Taras Y., Taras Y. Nechitaylo (8033432), Tobias Engl (6259)   +11 more
core   +1 more source