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Special Issue: HPV and HPV Vaccines [PDF]

Viruses, 2022
Our fundamental understanding of papillomaviruses and their interactions with their host, including their role in cancer and how the immune system responds to them, has made the elimination of cervical cancer a realistic global health goal [...]
openaire   +3 more sources

Human Papillomavirus E7 and p16^INK4a mRNA Multiplexed Quantification by a QuantiGene^TM Proof-of-Concept Assay Sensitively Detects Infection and Cervical Dysplasia Severity

Diagnostics, 2023
Background: Persistent infection with human papillomavirus (HPV) can lead to cervical cancer (CxCa). During the progression to CxCa, the expression of HPV oncogenes E6 and E7 is upregulated. In turn, cellular proteins such as p16INK4a are also modulated.
Anna Sophie Skof, Lina Rotenberg, Paul Viktor Felix Hannemann, Sarah Thies, Eleonora Boschetti-Grützmacher, Andreas M. Kaufmann   +5 more
doaj   +1 more source

Enhancement of specific T-lymphocyte responses by monocyte-derived dendritic cells pulsed with E2 protein of human papillomavirus 16 and human p16INK4A [PDF]

PeerJ, 2020
Introduction Prophylactic vaccines are already available for prevention of human papillomavirus (HPV) infection. However, we still await development of therapeutic vaccines with high efficiency for stimulating specific T lymphocytes to clear HPV ...
Nuchsupha Sunthamala, Neeranuch Sankla, Jureeporn Chuerduangphui, Piyawut Swangphon, Wanchareeporn Boontun, Supakpong Ngaochaiyaphum, Weerayut Wongjampa, Tipaya Ekalaksananan, Chamsai Pientong   +8 more
doaj   +2 more sources

Influence of resuspension volume on dry sampling devices taken for human papillomavirus testing: implications for self-sampling

BioTechniques, 2023
Optimization of technical parameters that influence the performance of human papillomavirus (HPV) testing on self-taken samples is important. Here, the authors assessed the impact of resuspension volume on the detection of HPV using four validated HPV ...
Linzi Connor, Hana Elasifer, Alex Sargent, Ramya Bhatia, Catriona Graham, Kate Cuschieri   +5 more
doaj   +1 more source

The recovery strategies to support cervical cancer elimination in lower-and middle-income countries (LMICs) following COVID-19 disruptions

Preventive Medicine Reports, 2023
The COVID-19 pandemic has exacerbated the existing challenges to achieving the WHO target of eliminating cervical cancer as a public health problem by working towards the target of fewer than four cases per 100 000 women.
Jieying Lee, Ida Ismail-Pratt, Dorothy A Machalek, Suresh Kumarasamy, Suzanne M. Garland   +4 more
doaj   +1 more source

TLR9 and Glioma: Friends or Foes?

Cells, 2022
Toll-like receptor 9 (TLR9) is an intracellular innate immunity receptor that plays a vital role in chronic inflammation and in recognizing pathogenic and self-DNA in immune complexes. This activation of intracellular signaling leads to the transcription
Emna Fehri, Emna Ennaifer, Rahima Bel Haj Rhouma, Monia Ardhaoui, Samir Boubaker   +4 more
doaj   +1 more source

Hemorragia Alveolar Difusa - a propósito de um caso clínico de Hemossiderose Pulmonar Idiopática.

Revista Portuguesa de Pneumologia, 1999
RESUMO: Devido à sua raridade, a Hemorragia Alveolar Difusa (HAD) é muitas vezes urn diagnóstico esquecido. Os autores apresentam uma revisião desta entidade a propósito do caso clínico de um homem de 71 anos, internado por febre, tosse seu ...
Paula Esteves, Luís Telo, Filipe Froes, Leonardo Ferreira, Cecìlia Nunes, Paula Duarte, Raul Amaral-Marques   +6 more
doaj   +1 more source

Angiofibroma juvenil da nasofaringe - Podemos dispensar a embolização pré-operatória?

Revista Portuguesa Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, 2012
O Angiofibroma juvenil da nasofaringe é uma mal-formação vascular rara, com aparente origem no buraco esfeno-palatino, mais frequente em jovens adolescentes do sexo masculino que assume, não raras vezes, um comportamento local agressivo, a que se ...
Joana Filipe, Teresa Matos, Helena Ribeiro, Luis Tomás, Paulo Borges Dinis   +4 more
doaj   +1 more source

Poliserosite

Revista Portuguesa de Pneumologia, 1999
RESUMO: No presente caso clínico descreve-se um doente com poliserosite, trombocitopénia autoimune e artrite não erosiva. Apresenta ainda lesões cutâneas sugestivas, mas não suficientemente expressivas para a sua inclusão nos critérios de Lupus ...
Carlos Boinas, José Albergaria Ambar, Casimiro Machado, Maria João Marques Gomes   +3 more
doaj   +1 more source

Mapping HPV 16 Sub-Lineages in Anal Cancer and Implications for Disease Outcomes

Diagnostics, 2022
The incidence of anal cancer is rising worldwide. As identified in cervical cancer management, an improvement in the early detection and management of anal pre-cancer is essential.
Daniel Guerendiain, Laila Sara Arroyo Mühr, Raluca Grigorescu, Matthew T. G. Holden, Kate Cuschieri   +4 more
doaj   +1 more source