Results 41 to 50 of about 198,913 (305)

Validation in Zambia of a cervical screening strategy including HPV genotyping and artificial intelligence (AI)-based automated visual evaluation

Infectious Agents and Cancer, 2023
Background WHO has recommended HPV testing for cervical screening where it is practical and affordable. If used, it is important to both clarify and implement the clinical management of positive results.
Groesbeck P. Parham, Didem Egemen, Brian Befano, Mulindi H. Mwanahamuntu, Ana Cecilia Rodriguez, Sameer Antani, Samson Chisele, Mukatimui Kalima Munalula, Friday Kaunga, Francis Musonda, Evans Malyangu, Aaron Lunda Shibemba, Silvia de Sanjose, Mark Schiffman, Vikrant V. Sahasrabuddhe   +14 more
doaj   +1 more source

Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow‐Dependent Endothelial Activation and Atherogenesis

Advanced Science, EarlyView.
Disturbed flow promotes the formation of TRIM21‐rich biomolecular droplets, which concentrate TRIM21 and PTPN14 and facilitate their SPRY‐FERM interaction (illustrated by the TRIM21 D355‐PTPN14 R132 salt bridge). This condensate‐driven proximity enables TRIM21 to catalyze K48‐linked polyubiquitination of PTPN14 at lysine 956, leading to proteasome ...
Xue He, Qiannan Ma, Xue Wang, Jiaxu Mang, Chufeng Li, Bingjun Wu, Liu Yao, Yequn Chen, Qiankun Bao, Yi Zhu, Jinlong He   +10 more
wiley   +1 more source

DDX21 Enhances Radiosensitivity in Head and Neck Squamous Cell Carcinoma by Suppressing MK2‐Mediated DNA Damage Response

Advanced Science, EarlyView.
DDX21 suppresses MK2 activation by directly inhibiting Thr334 phosphorylation in a p38‐independent manner, thereby impairing DNA damage response. Clinically, patients with well‐differentiated tumors exhibiting high DDX21 expression are more likely to benefit from adjuvant radiotherapy, whereas those with low DDX21 levels are predisposed to ...
Tianru Yang, Ting Shen, Yanfang Qiu, Wei Zhang, Ziran Zheng, Jiayi Sun, Yuedi Yao, Mianfeng Yao, Jiang Li   +8 more
wiley   +1 more source

An in vitro model and the underlying pathways of sinonasal inverted papilloma development

Scientific Reports, 2023
Recently, the specific association between Sinonasal inverted papilloma (SIP) and EGFR exon 20 mutations has been reported. To investigate the link between specific EGFR mutations and SIP development, we established organotypic raft culture system using ...
Thawaree Nukpook, Tohru Kiyono, Tipaya Ekalaksananan, Pornthep Kasemsiri, Watchareporn Teeramatwanich, Patravoot Vatanasapt, Surachat Chaiwiriyakul, Tomomi Nakahara, Chamsai Pientong   +8 more
doaj   +1 more source

Epidemiological evidence and association of human papillomavirus with esophageal cancer in northeastern Thailand: a case–control study

Frontiers in Microbiology, 2023
Recently, epidemiological evidence of high-risk human papillomavirus (hrHPV) and its association with the increasing risk of esophageal cancer (EC) have been described.
Ati Burassakarn, Ati Burassakarn, Chamsai Pientong, Chamsai Pientong, Panwad Tongchai, Weerayut Wongjampa, Weerayut Wongjampa, Arisara Poosari, Apiradee Udomsin, Prakasit Sa-ngiamwibool, Piti Ungareewittaya, Thitima Nutravong, Tipaya Ekalaksananan, Tipaya Ekalaksananan   +13 more
doaj   +1 more source

Molecular Landscapes of Tumor Dormancy in Gynecologic Malignancies: From Survival Mechanisms to Precision Interception

Advanced Science, EarlyView.
This Review outlines the biological framework of entry, maintenance, and awakening in dormant minimal residual disease across gynecologic cancers. By mapping critical biological dependencies—from metabolic plasticity to microenvironment interactions—it evaluates novel interception concepts and presents a translational framework combining single‐cell ...
Shih‐Hsuan Cheng, Ren‐Wang Peng, Chang‐Cheng Wu, Chi‐Wen Luo, Emmanuel Naveen Raj, Zhi‐Hong Wen, Tzu‐Hung Hsiao, Chia‐Jung Li   +7 more
wiley   +1 more source

Scaffold RNA Reengineering for a Leakage‐Suppressed CRISPR/Cas12a Cascade System Toward Precise Nucleic Acid Diagnostics

Advanced Science, EarlyView.
Schematic illustration of the CALCas system, in which a conformational switch in the 3' terminal DNA extension of scaffold RNA (3'D‐SR) drives cascade‐activatable Cas12a cleavage while suppressing leakage. ABSTRACT Amplification‐free CRISPR detection has attracted significant attention for its capacity to circumvent the intricacies of nucleic acid ...
Xingrong Li, Honghua Hu, Xinli Jiang, Xuhuai Fu, Lin Hu, Qinghua Wu, Jiatong Chai, Diangeng Li, Jinhong Guo, Zhiqiang Li, Yi Li, Yirong Li   +11 more
wiley   +1 more source

Limiar anaeróbico: comparação entre os métodos directos e indirectos em nadadores de alta competição Portugueses(+)(+) Trabalho apresentado sob forma de comunicação oral no II Congresso Hispano-Luso de Pneumologia. Sevilha, 21 de Abril de 1993 econcorrente ao Prémio Thomé Villar 1993 (Secção B). da SPPR.

Revista Portuguesa de Pneumologia, 1995
RESUMO: Com o objectivo de avaliar o limiar anaeróbico (AT) compara-se o ponto de rotura ventilatória ou “limiar ventilatório” (ATV) com a lactatémia de 4 mmol/1 (ATL).
Cecília Longo, João Paulo Almeida, E. Ramiro Ãvila   +2 more
doaj   +1 more source

Anal PAP, HPV tests and magnifying chromoendoscopy with biopsies in the diagnosis of anal intraephitelial neoplasia

Journal of Coloproctology, 2020
Introduction: Anal intraepithelial neoplasia (AIN) is the most likely precursor of squamous cells cancer which represents 90% of anal cancers. The use of biomolecular tests as a screening method has been extended by gynecology.
Carmen Aguiar, Laura García, María Belén Boccardo, Macarena Vassel, Alejandra Arriola, Sylvia Jaumandreu, María Carmen Rodríguez, Carmen Alvarez, Isabelle Heard   +8 more
doaj   +1 more source

Reduction of low- and high-grade cervical abnormalities associated with high uptake of the HPV bivalent vaccine in Scotland [PDF]

, 2014
In Scotland, a national HPV immunisation programme began in 2008 for 12-13 year olds, with a catch-up campaign from 2008-2011 for those under the age of 18.
Kavanagh, K, Cruickshank, M, Cubie, H., C Robertson, Pollock, Kevin G.J., J Love, Pollock, K G J, Potts, A., Love, J., K Kavanagh, Cruickshank, M., Nicoll, Sheila, Donaghy, Martin, Palmer, Tim J, K Cuschieri, Robertson, C, Palmer, T J, M Donaghy, Cuschieri, K., Robertson, C., H, Cubie,, Potts, Alison, H Cubie, M Cruickshank, Nicoll, S., Donaghy, M, Pollock, K. G. J., Potts, A, Love, John, Cuschieri, Kate, Kavanagh, K., Donaghy, M., S Nicoll, Cuschieri, K, Cubie, H, Nicoll, S, Cruickshank, Maggie, T J Palmer, Love, J, Kavanagh, Kimberley, K G J Pollock, Robertson, Chris, Palmer, T. J., A Potts   +43 more
core   +1 more source