Results 51 to 60 of about 74,023 (261)

Pneumonia da Comunidade em Portugal Continental – Internamentos Hospitalares em 1997

Revista Portuguesa de Pneumologia, 1999
RESUMO: OBJECTIVO: Caracterizar a incidência, a mortalidade e a etiologia da pneumonia adquirida na comunidade (PAC) em Portugal.DOENTES E MÉTODOS: Utilizou-se a base de dados clínica do IGIF do Ministério da Saude que possui a informação ...
Filipe Froes, Vicencia Ribeiro
doaj   +1 more source

Acceptability of unsupervised HPV self-sampling using written instructions

, 2006
Objectives The study measured the acceptability of self-sampling for human papillomavirus (HPV) testing in the context of cervical cancer screening. Women carried out self-sampling unsupervised, using a written instruction sheet.Setting Participants were
J Austin, A Szarewski, J Wardle, McCaffery, K, Cadman, L, J Waller, Forrest, S, L Cadman, Szarewski, A, K Mccaffery, Waller, J, Austin, J, Wardle, J, S Forrest   +13 more
core   +1 more source

HPV-aligned reads vs. total number of reads according to HPV status and number of HPV types in the samples.

, 2021
There was no difference in total reads number between positive samples (blue dots) and negative samples (red dots). In contrast, alignment of HPV reads depended on the HPV types in each positive sample (p−3): The aligned HPV reads were more numerous in ...
Thalja Laasili (11261538), Ikram Guizani (564611), Monia Ardhaoui (2833628), Anna Christina De Matos Salim (11261532), Flávio Marcom Gomez (11261535), Emna Ennaifer (2833637), Med Samir Boubaker (2833652)   +6 more
core   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Thermostable Bioluminescent Intercalating Dyes for Real‐Time, Integrated Nucleic Acid Amplification and Detection

Angewandte Chemie, EarlyView.
We present a bioluminescent diagnostic platform that integrates DNA amplification and detection in a single step. The engineering of thermostable luciferase‐intercalating dye conjugates and controlled release of caged luciferin substrates enable real‐time, detection of attomolar concentrations of viral DNA within 30 min.
Yosta de Stigter, Harmen J. van der Veer, Sterre de Lignie, Robbert J. de Haas, Renko de Vries, Joost P. H. Schoeber, Anne J. M. Loonen, Adriaan J. C. van den Brule, Maarten Merkx   +8 more
wiley   +2 more sources

No Vacillation on HPV Vaccination [PDF]

Cell, 2018
Evidence of the safety and protective benefits of human papillomavirus virus (HPV) vaccines as an anti-cancer measure is overwhelming. However, vaccine uptake varies widely across countries and falls short of levels needed to achieve population immunity. We highlight policy measures that would help ensure greater worldwide coverage and save lives.
Sipp, Douglas, Frazer, Ian H., Rasko, John E. J.   +2 more
openaire   +5 more sources

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Mitochondria‐Targeting Moieties Based on N‐Tethered Pyridinium Cations

Angewandte Chemie, EarlyView.
Pyridinium cations were benchmarked as mitochondria‐targeting moieties in a panel of N‐tethered fluorescent‐, bioactive‐, and inert‐cargo conjugates. 3,5‐Diphenylpyridinium (DPPy+) is a competent triphenylphosphonium (TPP+) surrogate, combining high mitochondria‐targeting efficiency with lower intrinsic effects on mitochondrial function.
Ivan Džajić, Natalija Trunkelj, Jernej Repas, Maša Kandušer, Lara Smrdel, Stane Pajk, Lovro Žiberna, Irena Mlinarič‐Raščan, Bostjan Markelc, Tim Bozic, Masa Omerzel, Tanja Jesenko, Maja Cemazar, Katja Kološa, Bojana Žegura, Miha Virant, Matic Lozinšek, Hai M. Nguyen, Joshua A. Nasburg, Heike Wulff, Maxime Gueguinou, Valerije Vrček, Veronica Carpanese, Ildiko Szabo, Luis A. Pardo, Tihomir Tomašič, Lucija Peterlin Mašič, Andrej Emanuel Cotman   +27 more
wiley   +2 more sources

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

Pooled analysis of HPV infection in paired anal and cervical samples, by HIV status

Papillomavirus Research, 2018
Background: In light of HPV16's unique carcinogenicity in the anus, knowledge of anal HPV16 prevalence may be a useful surrogate for stratifying groups of women at differing anal cancer risk based on routinely available cervical cancer screening outcomes.
Gary Clifford, IARC HPV study group.
doaj   +1 more source