Results 51 to 60 of about 500,134 (199)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

An Open-Source graphical tool for class E PA design exploration and optimization

Results in Engineering
This paper presents a novel platform for the efficient analysis, design, and optimization of ideal single-ended Class-E power amplifiers (PAs). It employs a comprehensive time-domain analytical model, which extends the conventional design space by ...
Pallab Kr Gogoi, Ştefan Ştefănescu, Jurgen Vanhamel, Jérôme Loicq   +3 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Descriptive epidemiology of gynecologic and breast cancers between 1988 and 2018 in Burkina Faso, West Africa

Journal of Interventional Epidemiology and Public Health
Introduction: Cancer remains a major public health concern due to its severity, its prevalence, and its high incidence. However, there are no data on its full extent in Burkina Faso given the lack of functioning national registry of cancer.
Smaila Ouedraogo, Nayi Zongo, Adeline Djiguemde, Hyacinthe Zaman, Aimé Sosthène Ouedraogo, Blandine Thieba   +5 more
doaj   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Kerosene-H2 blending effects on flame properties in a multi-fuel combustor

Fuel Communications
In this study, the macroscopic properties of kerosene-H2 blended flames are investigated in a multi-phase, multi-fuel combustor, focusing on the effects of increasing H2 blending fractions. The non-reacting flow field of the swirl-stabilized combustor is
Kaushal Dave, Sarah Link, Francesca De Domenico, Ferry Schrijer, Fulvio Scarano, Arvind Gangoli Rao   +5 more
doaj   +1 more source

Are We Eating Our Way to Prostate Cancer—A Hypothesis Based on the Evolution, Bioaccumulation, and Interspecific Transfer of miR-150

Non-Coding RNA, 2016
MicroRNAs (miRNAs) are well established epigenetic modifiers. There is a lot of work being done to identify the evolutionary transfer of miRNAs both at intra- and interspecific levels. In this hypothesis-driven review, we have suggested a possible reason
Venkatesh Vaidyanathan, Vetrivhel Krishnamoorthy, Nishi Karunasinghe, Anower Jabed, Radha Pallati, Chi Hsiu-Juei Kao, Alice Wang, Gareth Marlow, Lynnette R. Ferguson   +8 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Expanding Electric and Vehicle-Based Solar Transit Options with Breakthrough Vehicular Efficiencies

World Electric Vehicle Journal
Traditional approaches to overcoming energy loss from resistances of vehicular transit velocities have focused primarily on reducing aerodynamic drag through streamlining air flow.
Adam B. Suppes, Galen Suppes
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source