Results 21 to 30 of about 9,393 (131)

High-Grade Vaginal Intraepithelial Neoplasia: Clinical Profile, HPV Vaccination Status, and Treatment Outcomes at Two Italian Referral Centers

Vaccines
Background: There is limited available data about the natural history and clinical characteristics of patients affected by high-grade vaginal intraepithelial neoplasia (or vaginal intraepithelial neoplasia 2/3 or vaginal high-grade squamous ...
Niccolò Gallio, Mario Preti, Renzo Boldorini, Cristina Cavagnetto, Fulvio Borella, Federica Bevilacqua, Ilaria Barbierato, Raffaella Ribaldone, Enrica Bovio, Chiara Airoldi, Valentino Remorgida, Luca Marozio, Alberto Revelli   +12 more
doaj   +1 more source

A study on the correlation between HPV DNA and IHC P16 expression in cervical lesions [PDF]

Zhongguo aizheng zazhi
Background and purpose: Human papilloma virus (HPV) infection status is crucial for diagnosing cervical precancerous lesions and classifying cervical cancer.
WANG Haochen, JIA Liqing, YANG Yu, WANG Qian, YU Chengli, TIAN Tian, BI Rui, TU Xiaoyu, BAI Qianming, ZHU Xiaoli, ZHOU Xiaoyan, REN Min
doaj   +3 more sources

Prevalence of high-risk human papilloma virus in women with high-grade squamous cell intraepithelial lesions in Botswana using Abbott RealTime HPV assay.

PLoS ONE, 2019
BACKGROUND:High-risk human papillomavirus (HR-HPV) has been demonstrated to be the necessary cause of cervical carcinoma. High-risk HPV detection has a prognostic significance for the women who are at increased risk of disease progression. HPV genotyping
Patricia Rantshabeng, Ishmael Kasvosve, Andrew Ndlovu, Simani Gaseitsiwe, Sikhulile Moyo   +4 more
doaj   +1 more source

Health Care Policy Implementation Trial of Primary Human Papillomavirus–Based Cervical Screening in Denmark

International Journal of Cancer, EarlyView.
Uncertainty has persisted over whether human papillomavirus (HPV) testing outperforms high‐quality cytology in real‐world cervical cancer screening programs. To address this, Denmark launched a nationwide trial in 2021, implementing an HPV‐based screening strategy using specialized algorithms integrated with molecular and cytology triage to optimize ...
Jesper Bonde, Jeppe Bennekou Schroll, Birgitte Tønnes Pedersen, Elsebeth Lynge, Marianne Waldstrøm, Petra Hall Viborg, Anna Frandsen, Rikke Holst Andersen, Susanne Nielsen, Doris Schledermann, Bettina Kjær Kristensen, Berit Andersen, on behalf of the National Danish Cervical Cancer Screening Steering Committee   +12 more
wiley   +1 more source

HPV 16 detection in cervical lesions, physical state of viral DNA and changes in p53 gene

São Paulo Medical Journal
CONTEXT: Persistent infection with high risk human papillomavirus (HPV) has been linked to cervical carcinoma. Integration of viral DNA into host cell DNA is essential for this cancer development, promoting disruption of the HPV E2 gene, thus leading to ...
Ledy do Horto dos Santos Oliveira, Eliane de Vasconcelos Machado Rodrigues, Ana Paula Terra Alvim de Salles Lopes, André de Paula Fernandez, Silvia Maria Baeta Cavalcanti   +4 more
doaj   +1 more source

Triage Performance of FAM19A4/miR124‐2 Methylation: 18‐Month Follow‐Up Results From a Prospective Observational Study Within the Dutch Primary HPV‐Based Cervical Screening Program

International Journal of Cancer, EarlyView.
ABSTRACT DNA methylation analysis of the genes FAM19A4 and miR124‐2 has emerged as a promising triage strategy for high‐risk (hr) human papillomavirus (HPV)‐positive women in cervical screening. This study reports a prospective evaluation of the diagnostic accuracy of FAM19A4/miR124‐2 methylation in a large population‐based primary HPV‐based screening ...
Lisanne Verhoef, Mila S. Griffioen, Maaike C. G. Bleeker, John W. J. Hinrichs, Albert G. Siebers, Albertus T. Hesselink, Chris J. L. M. Meijer, Renske D. M. Steenbergen, Johannes Berkhof, Daniëlle A. M. Heideman   +9 more
wiley   +1 more source

Detection of abnormal cervical cytology in Papanicolaou smears

Journal of Cytology, 2012
Background: Cervical cytology by Papanicolaou (Pap) smears is an effective means of screening for cervical premalignant and malignant conditions. Cervical intra-epithelial neoplasia (CIN) and cervical cancer remain important health problems for women ...
Manjit Singh Bal, Rishu Goyal, Anil Kumar Suri, Manjit Kaur Mohi   +3 more
doaj   +1 more source

Yield of endocervical curettage in detecting cervical intraepithelial neoplasia grade 2 or higher during colposcopy: A prospective, cross‐sectional study

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 105-111, April 2025.
Abstract Objective This study assessed the prevalence and factors associated with detecting cervical intraepithelial neoplasia grade 2 or higher (CIN2+) via endocervical curettage (ECC) during colposcopy. Methods Between December 2020 and September 2023, a prospective, cross‐sectional study involving women with abnormal cervical cancer screening ...
Nida Jareemit, Lalita Theerarojanapong, Natthawadee Laokulrath, Vuthinun Achariyapota, Khemanat Khemworapong, Sompop Kuljarasnont, Pornporm Ittiamornlert, Vitcha Poonyakanok, Perapong Inthasorn   +8 more
wiley   +1 more source

Upregulation of HPV16E1 and E7 expression and FOXO3a mRNA downregulation in high-grade cervical neoplasia [PDF]

PeerJ
Background Cervical cancer remains a significant global health concern, ranking as the fourth most prevalent cancer among women worldwide. Human papillomaviruses (HPV) transcribe many genes that might be responsible for cervical cancer development.
Thanayod Sasivimolrattana, Aileen Gunawan, Warattaya Wattanathavorn, Chavis Pholpong, Arkom Chaiwongkot, Pattarasinee Bhattarakosol, Parvapan Bhattarakosol   +6 more
doaj   +2 more sources

Sequential gene expression analysis of cervical malignant transformation identifies RFC4 as a novel diagnostic and prognostic biomarker

BMC Medicine, 2022
Background Cervical squamous cell carcinoma (SCC) is known to arise through increasingly higher-grade squamous intraepithelial lesions (SILs) or cervical intraepithelial neoplasias (CINs).
Jianwei Zhang, Silu Meng, Xiaoyan Wang, Jun Wang, Xinran Fan, Haiying Sun, Ruoqi Ning, Bing Xiao, Xiangqin Li, Yao Jia, Dongli Kong, Ruqi Chen, Changyu Wang, Ding Ma, Shuang Li   +14 more
doaj   +1 more source