Results 171 to 180 of about 40,103 (213)
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HSP60, Bax, and Cardiac Apoptosis
Cardiovascular Toxicology, 2003HSP60 has long been known as an important chaperonin and as having key folding functions within the mitochondria. However, it has now become evident that significant amounts of HSP60 are found in extra-mitochondrial locations. This extra-mitochondrial HSP60 in the heart has key anti-apoptotic functions. Extra-mitochondrial HSP60 complexes with both bax
A A, Knowlton, S, Gupta
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Current Pharmaceutical Design, 2012
Heat shock proteins (HSPs) are ubiquitous and evolutionary conserved proteins induced by cell stress. HSP60, in particular, is a typical mitochondrial molecular chaperone that is known to assist nascent polypeptides to reach a native conformation. HSP60 is also known to interact with HSP10.
Hiroyuki Nakamura, Hidemitsu Minegishi
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Heat shock proteins (HSPs) are ubiquitous and evolutionary conserved proteins induced by cell stress. HSP60, in particular, is a typical mitochondrial molecular chaperone that is known to assist nascent polypeptides to reach a native conformation. HSP60 is also known to interact with HSP10.
Hiroyuki Nakamura, Hidemitsu Minegishi
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The HSP60 immune system network
Trends in Immunology, 2011Heat shock proteins (HSPs) were initially discovered as participants in the cellular response to stress. It is now clear, however, that self and microbial HSPs also play an important role in the control of the immune response. Here, we focus on HSP60 and its interactions with both the innate and adaptive immune system in mammals.
Francisco J, Quintana, Irun R, Cohen
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Hsp60 Involvement During Carcinogenesis
2019The implication of Hsp60 in cancer development is due to its participation in many metabolic and biomolecular mechanisms in cancer cells. Hsp60 interacts with various molecules that are responsible of apoptosis, cell proliferation and other mechanisms involved when a normal cell becomes malignant.
Francesca Rappa +2 more
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HSP60 and Anti-HSP60 Antibodies in Vasculitis: They are Two of a Kind
Clinical Reviews in Allergy & Immunology, 2008Clinical and pathological manifestations present as heterogeneous in vasculitides. Thus, inflammation can affect arteries, arterioles, capillaries, venules, and veins toward major body regions. One common feature of vascular diseases appears to be the presence of anti-HSP60 autoantibodies arising either consecutively to infection and molecular mimicry ...
Jean-Eric, Alard +3 more
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2015
Anti-Hsp60 antibodies has been detected in the plasma of most clinically healthy donors. It has been shown that newborns with congenital heart disease had the same levels of anti-Hsp60 antibodies that their mothers. In neonates who underwent corrective surgery for congenital heart defects using autologous umbilcal cord blood serum levels of anti-Hsp60 ...
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Anti-Hsp60 antibodies has been detected in the plasma of most clinically healthy donors. It has been shown that newborns with congenital heart disease had the same levels of anti-Hsp60 antibodies that their mothers. In neonates who underwent corrective surgery for congenital heart defects using autologous umbilcal cord blood serum levels of anti-Hsp60 ...
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Saccharomyces cerevisiae Hsp60
1997Abstract The HSP60 gene of Saccharomyces cerevisiae was identified in the conditional mutant mif4 that lacked enzymatic activity of imported ornithine transcarbamylase (Cheng et al., 1989). Concurrently, the yeast HSP60 gene was isolated by screening a A-gt11 genomic library with a polyclonal antiserum raised against purified Tetra ...
Langer, T., Neupert, W.
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Molecular Chaperone Disorders: Defective Hsp60 in Neurodegeneration
Current Topics in Medicinal Chemistry, 2013Chaperonins, a subgroup of molecular chaperones, form ring-shaped structures and assist folding of proteins by enclosing them in their inner cavity. The mitochondrial Hsp60/Hsp10 chaperonin system is essential for cell viability and only a very small number of mutations causing human disease have so far been found that appear to selectively affect ...
Bross, Peter +2 more
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