Results 101 to 110 of about 111,857 (291)

The remarkable multivalency of the Hsp70 chaperones

Cell stress & chaperones (Print), 2017
Hsp70 proteins are key to maintaining intracellular protein homeostasis. To carry out this task, they employ a large number of cochaperones and adapter proteins.
E. Zuiderweg, L. Hightower, J. Gestwicki
semanticscholar   +1 more source

Integrative Approaches to Treating Cellular Senescence in Kidney Disease

Advanced Science, EarlyView.
ABSTRACT Cellular senescence in the kidney plays a crucial role in the progression of acute kidney injury and chronic kidney disease. Therapeutic approaches targeting senescent cells, such as small molecule senolytic and senomorphic drugs, display efficacy in preclinical models.
Tomoka Misawa, Amruta A, LaTonya J. Hickson, Joy Wolfram   +3 more
wiley   +1 more source

The Gastroprotective Effects of Hydroalcoholic Extract of Monolluma quadrangula against Ethanol-Induced Gastric Mucosal Injuries in Sprague Dawley Rats [Retraction]

Drug Design, Development and Therapy, 2023
Ibrahim IAA, Abdulla M, Hajrezaei M, et al. Drug Des Devel Ther. 2016;10:93–105. We, the Editors and Publisher of Drug Design, Development and Therapy, have retracted the following article.
Ibrahim IAA, Abdulla M, Hajrezaei M, Bader A, Shahzad N, Al-Ghamdi SS, S. Gushash A, Hasanpourghadi M   +7 more
doaj  

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

Myopathy associated BAG3 mutations lead to protein aggregation by stalling Hsp70 networks

Nature Communications, 2018
BAG3 is a multi-domain hub that connects two classes of chaperones, small heat shock proteins (sHSPs) via two isoleucine-proline-valine (IPV) motifs and Hsp70 via a BAG domain.
Melanie Meister-Broekema, Rebecca Freilich, Chandhuru Jagadeesan, Chandhuru Jagadeesan, J. N. Rauch, R. Bengoechea, W. Motley, E. Kuiper, M. Minoia, G. Furtado, G. Furtado, M. A. V. Waarde, S. Bird, A. Rebelo, S. Züchner, P. Pytel, S. Scherer, F. Morelli, Serena Carra, Serena Carra, C. Weihl, Steven Bergink, J. Gestwicki, H. Kampinga   +23 more
semanticscholar   +1 more source

A Solution for Exosome‐Based Analysis: Surface‐Enhanced Raman Spectroscopy and Artificial Intelligence

Advanced Intelligent Discovery, EarlyView.
Exosomes are emerging as powerful biomarkers for disease diagnosis and monitoring. This review highlights the integration of surface‐enhanced Raman spectroscopy with artificial intelligence to enhance molecular fingerprinting of exosomes. Machine learning and deep learning techniques improve spectral interpretation, enabling accurate classification of ...
Munevver Akdeniz, Zakarya Al‐Shaebi, Omer Aydin   +2 more
wiley   +1 more source

Functions of J-domain proteins in mitochondrial protein biogenesis. [PDF]

Protein Sci
Abstract Mitochondrial biogenesis and functions depend on the import and assembly of more than 1000 proteins that are made as precursors on cytosolic ribosomes. The majority of these precursor proteins are transported from the ribosome to the translocase of the outer membrane (TOM complex), which constitutes the main entry site for mitochondrial ...
Tiku V, Bossenz G, Kirstein J, Becker T.
europepmc   +2 more sources

Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity

ACS Chemical Biology, 2018
As a key player of the protein quality control network of the cell, the molecular chaperone Hsp70 inhibits the aggregation of the amyloid protein tau. To date, the mechanism of this inhibition and the tau species targeted by Hsp70 remain unknown. This is
Franziska Kundel, S. De, Patrick Flagmeier, M. Horrocks, Magnus Kjaergaard, S. Shammas, S. Jackson, C. Dobson, D. Klenerman   +8 more
semanticscholar   +1 more source

Dual Functions of Dietary Rubber Seed Oil Supplementation: Enriching N‐3 Polyunsaturated Fatty Acids and Enhancing Antioxidant Capacity in Pekin Ducks

Animal Research and One Health, EarlyView.
Dietary RSO supplementation improved growth performance, simultaneously enriched n‐3 polyunsaturated fatty acids (n‐3 PUFA), and enhanced antioxidant capacity in Pekin ducks, which suggested that RSO has the potential to be a novel n‐3 PUFA source and an antioxidant for Pekin ducks to generate animal functional foods.
Lei Zhuang, Yongbao Wu, Zitao Zhao, Junting Cao, Yanhong Guo, Zhanyue Wu, Qimeng Wang, Peilong Yang, Sen Wu, Zhiguo Wen, Shuisheng Hou   +10 more
wiley   +1 more source

Immunoregulatory properties of Hsp70

Postępy Higieny i Medycyny Doświadczalnej, 2014
Heat shock proteins 70 (Hsp70) play an important role in maintaining cellular homeostasis. As molecular chaperones, Hsp70 are responsible for proper folding of newly synthesized polypeptides and refolding of misfolded and aggregated proteins. Hsp70 are involved in cellular transport and participate in signal transduction processes.
openaire   +2 more sources