Results 171 to 180 of about 73,273 (215)

Crystal structures reveal phosphorylation-dependent disruption of the heat shock protein 70-CHIP interface: A compensatory G132N variant restores binding affinity. [PDF]

Cell Stress Chaperones
Stewart M, Paththamperuma C, McCann C, Cottingim K, Zhang H, DelVecchio R, Peng I, Fennimore E, Nix JC, Saeed MN, George K, Makaroff K, Colie M, Paulakonis E, Almeida MF, Afolayan AJ, Brown NG, Page RC, Schisler JC.   +18 more
europepmc   +1 more source

Epoxy Clerodane Diterpene Attenuates the Differentiated Adipocyte Hypertrophy and Enhances Mitochondrial Metabolism

ChemistryOpen, Volume 15, Issue 7, July 2026.
Epoxy Clerodane Diterpene (ECD) significantly reduces adipocyte hypertrophy and lipid accumulation in human mesenchymal stem cell (hMSC)‐derived adipocytes. ECD improves mitochondrial membrane potential (ΔΨm), increases thermogenic regulators (UCP‐1, PPARγC1α), decreases adipogenic markers (C/EBPα, PPARγ), and reduces inflammatory mediators (TNF‐α, NF ...
Sahar Abdulaziz AlSedairy, Pandurangan Subash‐Babu, Maha H. Alhussain, Manal Abdulaziz Binobead, Ali A. Alshatwi   +4 more
wiley   +1 more source

Fenofibrate Mitigates Acute Lung Injury in a Rat Model of Feces-Induced Peritonitis. [PDF]

Int J Mol Sci
Akbaş A, Dasiran MF, Daghmoura H, Akbaş B, Aygun H, Serdaroglu A, Uyanikgil Y, Ercan G, Erbas O.   +8 more
europepmc   +1 more source

Redox signals and oxidative stress in the control of mitochondrial protein import

Protein Science, Volume 35, Issue 7, July 2026.
Abstract Mitochondrial protein import is essential for organelle biogenesis and cellular homeostasis. It operates in an environment that is intrinsically shaped by redox chemistry. Mitochondria are major sources of reactive oxygen species (ROS), which arise as by‐products of oxidative phosphorylation. Cells therefore maintain sophisticated ROS‐handling
Lidwina Hasberg, Viktoria Katharina Lauterbach, Torsten Ochsenreiter, Jan Riemer   +3 more
wiley   +1 more source

Structural insights into HRI kinase activity and inhibition. [PDF]

Biochem Soc Trans
Cao M, Masson GR.
europepmc   +1 more source

Caffeine Exposure Alters Neurotransmission and Stress Physiology in a Freshwater Gastropod. [PDF]

Toxics
Mohamed-Benhamu A.
europepmc   +1 more source

Photodynamic therapy with zinc phthalocyanine suppresses immune checkpoints in human melanoma cells. [PDF]

Lasers Med Sci
Doustvandi MA, Hajizadeh M, Mohammadnejad F, Karamali N, Yari AH, Nobari SA, Baradaran B.   +6 more
europepmc   +1 more source

Sarcolipin but not phospholamban responds to <i>in-vivo</i> heat stress in rat skeletal muscle similar to the 70-kDa heat shock protein. [PDF]

Front Physiol
Brahmbhatt AN, Chan JZ, Tomczewski MV, Humaid A, Gallichan HI, Flanagan J, Duncan RE, Tupling AR.   +7 more
europepmc   +1 more source

Tuning the Hsp70 chaperone cycle: emerging roles of GrpE-like nucleotide exchange factors in proteostasis and organelle function. [PDF]

Protein Cell
Morizono MA, Safar TV, Herzik MA.
europepmc   +1 more source

Emerging perspectives in proteostasis: bridging mechanisms and therapeutics for human diseases. [PDF]

Signal Transduct Target Ther
Borlepawar A, Neu M, Ma Z, Deshpande A, Bühringer H, Hajieva P, Frey N, Rangrez AY.   +7 more
europepmc   +1 more source