Results 221 to 230 of about 158,688 (339)

NAD⁺ restores proteostasis through splicing-dependent autophagy. [PDF]

Autophagy
Ai R, Fang EF.
europepmc   +1 more source

The ribosome‐associated complex regulates cytosolic translation upon mitoprotein‐induced stress

The FEBS Journal, EarlyView.
Defects in mitochondrial protein import trigger a stress response. The contribution of translation regulation to such a response is only partially understood. We demonstrate that the deletion of mitochondrial surface proteins (TOM70/TOM71) leads to defects in mitochondrial biogenesis and slow growth.
Jiaxin Qian, Annika Nutz, Katja Hansen, Lea Bertgen, Mirita Franz‐Wachtel, Boris Macek, Johannes M. Herrmann, Doron Rapaport   +7 more
wiley   +1 more source

Design and evaluation of an HSP70-targeting PROTAC in synergy with an HSF1 inhibitor for enhanced antitumor activity. [PDF]

RSC Med Chem
Huang WH, Mao TY, Dai GY, Ye JM, Li JB, Chen SB, Tan JH, Huang ZS, Huang SL.   +8 more
europepmc   +1 more source

Stress-induced localization of HSPA6 (HSP70B′) and HSPA1A (HSP70-1) proteins to centrioles in human neuronal cells [PDF]

, 2013
Sam Khalouei, Ari M. Chow, Ian R. Brown
openalex   +1 more source

The ALS‐associated E425K mutation uncouples DNAJC7 from the Hsp70 chaperone cycle

The FEBS Journal, EarlyView.
DNAJC7 is a J‐domain protein that plays a key role in protein quality control by regulating Hsp70 activity and preventing protein aggregation. We find that the ALS‐associated E425K mutation in DNAJC7 disrupts productive interaction and activation of Hsp70, thereby blocking the transfer and refolding of client proteins such as TDP‐43.
Bar Elmaleh, Ofrah Faust, Rina Rosenzweig   +2 more
wiley   +1 more source

Chronic Treatment with Curcumin Prevents Vascular Dysfunction in the Aorta of Type 1 Diabetes by Restoring Ca²⁺ Mishandling and Modulating HSP70 Levels. [PDF]

Cells
Rastogi S, Grimm A, Biby B, Mathieu L, Trinh B, Nunes KP.   +5 more
europepmc   +1 more source

The Mammalian Disaggregase Machinery: Hsp110 Synergizes with Hsp70 and Hsp40 to Catalyze Protein Disaggregation and Reactivation in a Cell-Free System

, 2011
James Shorter
openalex   +2 more sources

Extracellular vesicles released from melanoma cells constitutively expressing MHC class II promote immune evasion and cancer progression

The FEBS Journal, EarlyView.
Here, we report the role of extracellular vesicles (EVs) released from melanoma cells constitutively expressing MHC class II in the regulation of immune cell functions and melanoma metastasis. In particular, we observed an increased localization of HLA‐DRα, CAM receptors, PD‐L1, and STAT3 signaling proteins in the EVs.
Francesca Costantini, Caterina Di Sano, Samuele Raccosta, Mauro Manno, Giovanna Barbieri   +4 more
wiley   +1 more source

Increased circulating heat shock protein Hsp70 serum levels as a potential biomarker in bronchial asthma patients. [PDF]

Sci Rep
Churyukina E, Oganesyan E, Ukhanova O, Kotieva I, Gulyan M, Koreeva E, Portnyaga E, Bobkov D, Combs SE, Shevtsov M.   +9 more
europepmc   +1 more source

Non-Lethal Heat Shock Increased Hsp70 and Immune Protein Transcripts but Not Vibrio Tolerance in the White-Leg Shrimp

, 2013
Nguyen Hong Loc, Thomas H. MacRae, Najiah Musa, Muhd Danish‐Daniel, Mohd Effendy Abdul Wahid, Yeong Yik Sung   +5 more
openalex   +2 more sources