Results 231 to 240 of about 111,857 (291)

Toxic mechanisms of amyloid oligomers and therapeutic strategies

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Amyloid oligomers are increasingly recognized as the major toxic contributors across protein‐misfolding disorders. In this review, we cover mechanistic evidence showing how these transient and structurally heterogeneous oligomers disrupt cellular homeostasis by: (i) permeabilizing lipid membranes and forming ion‐conducting pores; (ii ...
Magdalena I. Ivanova, Carmelo La Rosa, Ayyalusamy Ramamoorthy   +2 more
wiley   +1 more source

Hsp70-Bim interaction mediated mitophagy as a potential therapeutic target for CML stem cells. [PDF]

Stem Cell Reports
Song T, Song Y, Zhang H, Hu Z, Yin F, Jiang M, Zhang Y, Wang Z, Zhang Z.   +8 more
europepmc   +1 more source

Impact of Fire and Heat Stress on Soil Microorganisms: A Review of Community Changes, Molecular Responses and Plant‐Beneficial Roles

Environmental Microbiology Reports, Volume 18, Issue 2, April 2026.
This work reviewed the direct and indirect effects of fires on microbial communities and the resilience strategies microbes use to withstand high temperatures . ABSTRACT Fire, whether occurring on the surface or underground, significantly influences soil microbial dynamics by reshaping community composition, functional diversity and overall soil and ...
Ma. del Carmen Orozco‐Mosqueda, Aurora Flores‐Piña, Ajay Kumar, Fannie I. Parra‐Cota, Sergio de los Santos‐Villalobos, Debasis Mitra, Olubukola Oluranti Babalola, Gustavo Santoyo   +7 more
wiley   +1 more source

Investigating the Potential Role of Capsaicin in Facilitating the Spread of Coxsackievirus B3 via Extracellular Vesicles. [PDF]

Int J Mol Sci
Chatterjee S, Kordbacheh R, Tilley H, Briordy D, Waldron RT, Cutts WD, Aleman J, Cook A, Dhanji R, Wong LR, Pandol SJ, Kim BJ, Fairweather D, Sin J.   +13 more
europepmc   +1 more source

Biomolecular Changes Upon Ablative Laser Therapy of the Skin: A Scoping Review

International Journal of Dermatology, Volume 65, Issue 4, Page 753-762, April 2026.
(Fractional) ablative laser therapy results in a wound healing response characterized by an inflammatory phase, dermal matrix degradation, and remodeling, collagenesis and elastogenesis. This is characterized by an increase in metalloproteinases, collagen type I, III, VII, and tropoelastin.
Marie‐Eline Pauline Henriette Debeuf, Maartje Hendrika Pieternel Rauwenhoff, Michel van Geel, Peter Martin Steijlen, Valerie Lydie Roland Marc Verstraeten   +4 more
wiley   +1 more source

Targeting and dissociating HIF2α from the molecular chaperone Hsp70 triggers apoptosis in kidney cancer. [PDF]

Commun Med (Lond)
Heritz JA, Backe SJ, Pacherille A, Cayaban SJ, Basin MF, Smith B, Sager RA, Daneshvar M, Post DE, Woodford MR, Bourboulia D, Chisholm JD, Mollapour M, Bratslavsky G.   +13 more
europepmc   +1 more source

Circular RNA Vv‐circCOR27 modulates thermotolerance through attenuating VvHSP90.2b‐VvHsfA7a interaction in grapevine

New Phytologist, Volume 250, Issue 2, Page 988-1003, April 2026.
Summary Circular RNAs (circRNAs) are single‐stranded, covalently closed RNA molecules that arise from exon back‐splicing. The identification and function investigation of circRNAs have been comprehensively explored in plants, however, the regulatory mechanisms are largely unknown.
Yi Ren, Yuanyuan Xu, Moyang Liu, Lipeng Zhang, Yue Song, Junpeng Li, Jingjing Liu, Dongying Fan, Zhen Zhang, Juan He, Jiuyun Wu, Qian Zha, Zhen Gao, Zheng'an Yang, Chao Ma   +14 more
wiley   +1 more source

Disulfide Crosslinking Induces Rapid Degradation of Arc/Arg3.1 via Hsp70‐Mediated Ubiquitin Ligase Pathway

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Heat shock induces Arc/Arg3.1 Cys34‐Cys159 disulfide crosslinking, promoting oligomerization and Hsp70‐CHIP‐dependent ubiquitination followed by proteasomal degradation during recovery. Disrupting disulfide formation (C159A) impairs CHIP‐mediated ubiquitination and stabilizes Arc/Arg3.1, whereas HSF1 loss limits inducible Hsp70 and leads to Arc ...
Dami So, In‐Kang Song, Yeon Jung Kim, Yeonjoo Lee, Yeon Seung Park, Hee‐Jung Kim, Kong‐Joo Lee, Eun Joo Song   +7 more
wiley   +1 more source

E-Selectin-Targeted Nanomicelles via Sialic Acid Conjugation for Anti-Inflammatory Efficacy and Alleviating the Progression of Metabolic-Associated Steatotic Liver Disease. [PDF]

Biomater Res
Zhang C, Zhang C, Sun Q, Wu H, Yin W, Zhu H, Huang S, Zhang Z, Zou Y, Wen D, Xu X, Lian M, Sun C, Tai S.   +13 more
europepmc   +1 more source

Laurdan: Clarifying Photophysics and Advancing the Characterization of Extracellular Vesicles

ChemPhysChem, Volume 27, Issue 5, 13 March 2026.
Biophysical properties of extracellular vesicles (EVs) reflect their composition and membrane organization. We introduce a novel approach using time‐resolved emission spectra (TRES) phasor analysis of the polarity‐sensitive probe Laurdan to characterize membranes with complex compositions.
Petra Riegerová, Mariana Amaro, Peter Kapusta, Antonín Vlček, Martin Smolko, Karel Souček, Vendula Pospíchalová, Martin Hof, Šárka Pokorná   +8 more
wiley   +1 more source