Results 261 to 270 of about 138,190 (352)

A YAP/TAZ–CDC6 Axis Initiates and Maintains Malignant Transformation

Cancer Science, Volume 117, Issue 2, Page 353-363, February 2026.
This study demonstrates that constitutive activation of YAP or TAZ is sufficient to induce and maintain malignant transformation in fibroblasts, identifying them as essential oncogenic drivers. Transcriptomic and functional analyses revealed CDC6 as a critical downstream effector of YAP/TAZ, with elevated expression linked to tumorigenesis across ...
David Nduru, Yudai Ohta, Akihiro Nita, Mayumi Niimura, Samson Ngurari, Toshiro Moroishi   +5 more
wiley   +1 more source

Phytochemical Profiling and Structure-Based Computational Characterization of <i>Marrubium vulgare</i> L. Compounds as Hsp90 Modulators. [PDF]

Int J Mol Sci
Zarguan I, Abbou H, Zegrari R, Festali R, Buchanan D, Benjouad A, Belayachi L.   +6 more
europepmc   +1 more source

Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase

Science, 2016
K. Verba, R. Wang, Akihiko Arakawa, Yanxin Liu, M. Shirouzu, S. Yokoyama, D. Agard   +6 more
semanticscholar   +1 more source

Hsp90-Cdc37 Chaperone Complex Regulates Ulk1- and Atg13-Mediated Mitophagy [PDF]

, 2011
Joung Hyuck Joo, Frank C. Dorsey, Aashish Joshi, Kristin M. Hennessy-Walters, Kristie L. Rose, Kelly McCastlain, Ji Zhang, Rekha Iyengar, Chang Hwa Jung, Der-Fen Suen, Meredith A. Steeves, Chia-Ying Yang, Stephanie M. Prater, Do‐Hyung Kim, Craig B. Thompson, Richard J. Youle, Paul A. Ney, John L. Cleveland, Mondira Kundu   +18 more
openalex   +1 more source

HSP90 buffers deleterious genetic variations in BRCA1. [PDF]

Mol Cell
Gracia B, Zhang XH, Montes P, Pham TC, Huang M, Chen J, Karras GI.   +6 more
europepmc   +1 more source

A phase Ib/II trial of XL888 (HSP90 inhibitor) and pembrolizumab in metastatic pancreatic cancer with translational immune profiling. [PDF]

Cancer Lett
Horvat NK, Diab M, Phillips MJ, McCook-Veal A, Grundy EE, Alese OB, Greene E, Gbolahan O, Coleman K, Doxie D, Herting CJ, Hammons J, Mahdi Z, Switchenko JM, Paulos CM, El-Rayes BF, Lesinski GB.   +16 more
europepmc   +1 more source

The interplay between inhibition of JAK2 and HSP90 [PDF]

, 2012
Jordan S. Fridman, Nicholas J. Sarlis
openalex   +1 more source

Heat Shock Proteins in Head and Neck Squamous Cell Carcinoma. [PDF]

Cells
Cierpikowski P, Bar J.
europepmc   +1 more source

Galleria mellonella infected with Bacillus thuringiensis involves Hsp90

Open Life Sciences, 2013
Wojda Iwona, Kowalski Patryk
doaj   +1 more source

Prediction of new C-terminal Hsp90 inhibitors based on deguelin scaffold: homology modeling, virtual screening, QM/MM docking, MM/GBSA, and molecular dynamics simulations. [PDF]

Res Pharm Sci
Abbasi M, Talaei S, Farshidfar G.
europepmc   +1 more source