Results 241 to 250 of about 109,885 (301)

Transcriptional responses to proteotoxic stressors are profoundly diverse and tissue-specific. [PDF]

Cell Stress Chaperones
Rabenius A, Salim I, Lindström H, Pak A, Aktay S, Vihervaara A.   +5 more
europepmc   +1 more source

Long‐Term Stress Adaptation as a Highly‐Conserved Key Factor in Yeast Aging

Aging Cell, Volume 25, Issue 5, May 2026.
This study shows that long‐term, but not short‐term, stress exposure triggers molecular changes in yeast that mirror established hallmarks of aging, including altered proteostasis, epigenetic shifts, and reduced lifespan. These changes are reversible upon stress removal, and the genes involved are conserved across all domains of life. ABSTRACT Aging is
Yanzhuo Kong, Damola Adejoro, Christopher Winefield, Stephen L. W. On, Philip A. Wescombe, Arvind Subbaraj, Andrew Saunders, Venkata Chelikani   +7 more
wiley   +1 more source

The dihydropyridine LA1011 modulates multiple Hsp90-co-chaperone interactions relevant to Alzheimer's disease. [PDF]

Cell Stress Chaperones
Jeanne X, Oberoi J, Roe MS, Baud M, Spencer J, Torok Z, Vigh L, Prodromou C.   +7 more
europepmc   +1 more source

Hsp90 in Cancer [PDF]

, 2016
openaire   +1 more source

Histone Deacetylase 9 Gene Deletion Ameliorates Aging‐Related Adipose Tissue Senescence and Mitochondrial Dysfunction in Mice

Aging Cell, Volume 25, Issue 5, May 2026.
Cellular senescence and mitochondrial dysfunction disrupt adipose tissue homeostasis during aging, but mechanisms remain unclear. HDAC9 expression increases with age in mouse adipose tissue and Hdac9 knockout mice showed reduced fat mass, senescence markers, and enhanced mitochondrial gene expression, respiration, and thiosulfate sulfurtransferase (Tst)
Brandee Goo, Samah Ahmadieh, Praneet Veerapaneni, Hong Shi, David S. Kim, Mourad Ogbi, Ronnie Chouhaita, Nicole Cyriac, Stephen Cave, Lingling Liu, Yong Zhang, Quansheng Du, Ha Won Kim, Yun Lei, Xin‐Yun Lu, Neal L. Weintraub   +15 more
wiley   +1 more source

Targeting Hsp90 in Cancer for 25 Years: Failure of Previous Clinical Trials and New Hope for Future Therapeutics. [PDF]

Cells
Chen M, Chang C, Miao KL, Woodley DT, Li W.   +4 more
europepmc   +1 more source

Small Cell Lung Cancer Establishes a Metabolic Autocrine Mechanism Through Active Extracellular ATP Transport

Cancer Science, Volume 117, Issue 5, Page 1333-1345, May 2026.
Small cell lung cancer (SCLC) actively exports ATP through PANX1 channels, triggering P2RX7‐mediated autocrine signaling and promoting tumor proliferation. Inhibition of PANX1 or P2RX7 disrupts this loop and suppresses tumor growth. ABSTRACT Small cell lung cancer (SCLC) is an aggressive malignancy with a 5‐year survival rate of less than 7%.
Takeshi Tsuruda, Manabu Kodama, Keiichi I. Nakayama   +2 more
wiley   +1 more source

Differential roles of HSP70 and HSP90 in Senecavirus A infection: IRES-dependent translational regulation and viral replication mechanisms. [PDF]

Virulence
Li C, Ma Y, Liu C, Xu S, Shi J, Li J.
europepmc   +1 more source

From Adipose Tissue to Cardiac Repair: Extracellular Vesicles in Cardiovascular Regeneration

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Adipose‐derived extracellular vesicles (ADEVs) secreted by adipose tissue have gained increasing attention due to their regenerative and immunomodulatory properties in cardiovascular diseases. They carry proteins, lipids, and nucleic acids that mediate intercellular communication and influence cardiac pathophysiology. In atherosclerosis, ADEVs
Karolina Ignaczak, Pola Ochocka, Karol Sadowski, Weronika Ploch, Dominika Tomkiel, Mariusz Tomaniak, Wioletta Olejarz   +6 more
wiley   +1 more source

Mitophagy‐Oxidative Stress Molecular Subtypes Define an Immunosuppressive Ecosystem and Vulnerabilities in Glioblastoma

Journal of Cellular and Molecular Medicine, Volume 30, Issue 10, May 2026.
ABSTRACT Glioblastoma (GBM) is an aggressive brain tumour with an immunosuppressive environment and poor prognosis; however, the roles of mitophagy and oxidative stress in its prognosis remain underexplored. This study analysed multi‐omics data from TCGA‐GBM (n = 168) and two GEO cohorts (GSE43378, n = 50; GSE147352, n = 85), compiling 603 mitophagy ...
Changjiang He, Yang Wang, Hongliang Zhong   +2 more
wiley   +1 more source