Results 231 to 240 of about 109,885 (301)

Development of a chaperone-mediated protein degrader targeting ERK5 that efficaciously reduces tumor growth. [PDF]

Cell Commun Signal
Yang X, Yin W, Xu M, Tusa I, Menconi A, Dai Y, Ding Q, Wang G, Foley KP, Rovida E, Ying W.   +10 more
europepmc   +1 more source

Dual Inhibitors of KRASG12D and HSP90 Are Effective against KRASG12D Inhibitor Resistance. [PDF]

Mol Cancer Ther
Pulido I, Gunder LC, Ying C, Wang Y, Dai Y, Yang Z, Rahnama A, Li J, Sun Y, Liu C, Zhou H, Wang G, Foley KP, Abdelhady K, Massad MG, Prince TL, Papautsky I, Ying W, Shimamura T.   +18 more
europepmc   +1 more source

NN-01-195, a novel conjugate of HSP90 and AURKA inhibitors, effectively targets solid tumors. [PDF]

Mol Cancer Ther
Nguyen TT, Nandwana NK, Srikanth YVV, Bagnyukova T, Chkalo O, Cai KQ, Lamperelli J, Pirestani S, Mehra MK, Burtness BA, Borghaei H, Akunuri R, Cassel J, Lu L, Salvino JM, Golemis EA.   +15 more
europepmc   +1 more source

Quality control of protein import into mammalian mitochondria

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Mitochondrial function depends on the continuous import of hundreds of nuclear‐encoded proteins. Targeting and translocation of mitochondrial proteins is a multistep process that is inherently vulnerable to defects in cytosolic quality control systems as well as perturbations in mitochondrial protein import machinery and organelle function ...
Madeleine Goldstein, Laurie Lee‐Glover, Hilla Weidberg   +2 more
wiley   +1 more source

Therapeutic Targets for Overcoming BCR::ABL1 Tyrosine Kinase Inhibitor Resistance in Chronic Myeloid Leukemia. [PDF]

Oncol Res
Tsubaki M, Matsuo T, Komori R.
europepmc   +1 more source

Comparative Analysis of Heat Exposure‐Induced Molecular Changes in Two Turtle Species with Contrasting Thermal Adaptations

Integrative Zoology, Volume 21, Issue 3, Page 609-623, May 2026.
Protein processing in the endoplasmic reticulum is highlighted in response to heat stress in Platysternon megacephalum. Under heat stress, the up‐regulation of genes such as CHOP in protein processing in the endoplasmic reticulum pathway, along with the suppression of energy and lipid metabolism and the up‐regulation of JARID2 expression, leads to ...
Jian Hong, Yangchun Gao, Jiaxuan Li, Yan Ge, Yufeng Wei, Youqiang Yin, Qianru Liang, Shiping Gong   +7 more
wiley   +1 more source

Koumine exerts its anti-colorectal cancer effects by disrupting the interaction between HSP90 and CDC37, thereby downregulating downstream signaling pathways. [PDF]

Front Oncol
Lin H, Bao Y, Cheng X, Zhang S, Zhou D, Que W.   +5 more
europepmc   +1 more source

UNC45B Reduction With Aging: A Myofiber‐Intrinsic Promoting Factor for Sarcopenia

Aging Cell, Volume 25, Issue 5, May 2026.
Aging reduces Unc45b expression in fast‐twitch muscle, concomitant with reduction in muscle contractile capacity and muscle mass in mice. Unc45b deficiency initially reduces depolarization‐induced force, followed by a decline in fast‐twitch muscle mass in adult mice.
Taiga Mishima, Taiga Nagamune, Saori Tada, Daiki Watanabe, Nao Tokuda, Takashi Yamada, Akiko Hashimoto‐Hachiya, Sayaka Higo‐Yamamoto, Kohei Kido, Noriyuki Nagaoka, Aoi Ikedo, Yuuki Imai, Ryo Fujita, Seiya Mizuno, Satoru Takahashi, Katsutaka Oishi, Satoru Ato, Riki Ogasawara   +17 more
wiley   +1 more source

FAM162A Is a Key Regulator of Mitochondrial Structure, Dynamics, and Bioenergetics, Driving Cellular Protection and Longevity

Aging Cell, Volume 25, Issue 5, May 2026.
FAM162A, localized within mitochondrial cristae, emerges as a novel regulator of mitochondrial dynamics. It post‐translationally modulates OPA1, maintaining cristae structure and boosting cellular bioenergetics. This key interaction enhances cell viability, stress resistance, and overall organismal health.
Andrea Matamoros, Juan Pablo Soffia, Marcelo Muñoz, Michael Maturana, Ma Andreina Rangel‐Ramirez, Alvaro Gonzalez‐Ibañez, Gabriela Gómez‐Lillo, Cesar Astorga, Lina M. Ruiz, Ramón A. Jorquera, Alejandra San Martín, Alvaro A. Elorza   +11 more
wiley   +1 more source